2h5l: Difference between revisions

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[[Image:2h5l.png|left|200px]]


{{STRUCTURE_2h5l| PDB=2h5l | SCENE= }}
==S-Adenosylhomocysteine hydrolase containing NAD and 3-deaza-D-eritadenine==
<StructureSection load='2h5l' size='340' side='right'caption='[[2h5l]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2h5l]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H5L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H5L FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3DD:(2R,3R)-4-(4-AMINO-1H-IMIDAZO[4,5-C]PYRIDIN-1-YL)-2,3-DIHYDROXYBUTANOIC+ACID'>3DD</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h5l OCA], [https://pdbe.org/2h5l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h5l RCSB], [https://www.ebi.ac.uk/pdbsum/2h5l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h5l ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SAHH_RAT SAHH_RAT] Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h5/2h5l_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2h5l ConSurf].
<div style="clear:both"></div>


===S-Adenosylhomocysteine hydrolase containing NAD and 3-deaza-D-eritadenine===
==See Also==
 
*[[S-adenosylhomocysteine hydrolase|S-adenosylhomocysteine hydrolase]]
{{ABSTRACT_PUBMED_17214973}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
[[2h5l]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H5L OCA].
 
==Reference==
<ref group="xtra">PMID:017214973</ref><references group="xtra"/>
[[Category: Adenosylhomocysteinase]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Komoto, J.]]
[[Category: Komoto J]]
[[Category: Takusagawa, F.]]
[[Category: Takusagawa F]]
[[Category: Yamada, T.]]
[[Category: Yamada T]]
[[Category: Hydrolase]]
[[Category: Hypocholesterolemic activity]]
[[Category: Inhibitor]]
[[Category: S-adenosylhomocysteine]]
Retrieved from "https://proteopedia.org/2h5l"