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[[Image:2gqq.png|left|200px]]


{{STRUCTURE_2gqq| PDB=2gqq | SCENE= }}
==Crystal Structure of E. coli Leucine-responsive regulatory protein (Lrp)==
<StructureSection load='2gqq' size='340' side='right'caption='[[2gqq]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2gqq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GQQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GQQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gqq OCA], [https://pdbe.org/2gqq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gqq RCSB], [https://www.ebi.ac.uk/pdbsum/2gqq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gqq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LRP_ECOLI LRP_ECOLI] Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gq/2gqq_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gqq ConSurf].
<div style="clear:both"></div>


===Crystal Structure of E. coli Leucine-responsive regulatory protein (Lrp)===
==See Also==
 
*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
{{ABSTRACT_PUBMED_17223133}}
__TOC__
 
</StructureSection>
==About this Structure==
[[2gqq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GQQ OCA].
 
==Reference==
<ref group="xtra">PMID:017223133</ref><references group="xtra"/>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Perona, J J.]]
[[Category: Large Structures]]
[[Category: Rios, S de los.]]
[[Category: Perona JJ]]
[[Category: Helix-turn-helix]]
[[Category: De los Rios S]]
[[Category: Transcription]]
Retrieved from "https://proteopedia.org/2gqq"