2exg: Difference between revisions

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[[Image:2exg.png|left|200px]]


{{STRUCTURE_2exg|  PDB=2exg  |  SCENE=  }}
==Making Protein-Protein Interactions Drugable: Discovery of Low-Molecular-Weight Ligands for the AF6 PDZ Domain==
 
<StructureSection load='2exg' size='340' side='right'caption='[[2exg]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
===Making Protein-Protein Interactions Drugable: Discovery of Low-Molecular-Weight Ligands for the AF6 PDZ Domain===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2exg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EXG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EXG FirstGlance]. <br>
 
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=STF:(5R)-2-SULFANYL-5-[4-(TRIFLUOROMETHYL)BENZYL]-1,3-THIAZOL-4-ONE'>STF</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2exg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2exg OCA], [https://pdbe.org/2exg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2exg RCSB], [https://www.ebi.ac.uk/pdbsum/2exg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2exg ProSAT]</span></td></tr>
[[2exg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EXG OCA].  
</table>
 
== Disease ==
==Reference==
[[https://www.uniprot.org/uniprot/AFAD_HUMAN AFAD_HUMAN]] Note=A chromosomal aberration involving MLLT4 is associated with acute leukemias. Translocation t(6;11)(q27;q23) with MLL/HRX. The result is a rogue activator protein.
<ref group="xtra">PMID:016671149</ref><references group="xtra"/>
== Function ==
[[Category: Homo sapiens]]
[[https://www.uniprot.org/uniprot/AFAD_HUMAN AFAD_HUMAN]] Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton.
[[Category: Boisguerin, P.]]
== Evolutionary Conservation ==
[[Category: Joshi, M.]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: Krause, G.]]
Check<jmol>
[[Category: Oschkinat, H.]]
  <jmolCheckbox>
[[Category: Schade, M.]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ex/2exg_consurf.spt"</scriptWhenChecked>
[[Category: Vargas, C.]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2exg ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Boisguerin, P]]
[[Category: Joshi, M]]
[[Category: Krause, G]]
[[Category: Oschkinat, H]]
[[Category: Schade, M]]
[[Category: Vargas, C]]
[[Category: Cell adhesion]]
[[Category: Cell adhesion]]
[[Category: Inhibitors of protein-protein interaction]]
[[Category: Inhibitors of protein-protein interaction]]
Retrieved from "https://proteopedia.org/2exg"