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[[Image:2g95.png|left|200px]]


{{STRUCTURE_2g95|  PDB=2g95  |  SCENE=  }}
==Crystal Structure of Visfatin/Pre-B Cell Colony Enhancing Factor 1/Nicotinamide Phosphoribosyltransferase==
 
<StructureSection load='2g95' size='340' side='right'caption='[[2g95]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
===Crystal Structure of Visfatin/Pre-B Cell Colony Enhancing Factor 1/Nicotinamide Phosphoribosyltransferase===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2g95]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G95 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G95 FirstGlance]. <br>
{{ABSTRACT_PUBMED_16901503}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g95 OCA], [https://pdbe.org/2g95 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g95 RCSB], [https://www.ebi.ac.uk/pdbsum/2g95 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g95 ProSAT]</span></td></tr>
==About this Structure==
</table>
[[2g95]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G95 OCA].  
== Function ==
[https://www.uniprot.org/uniprot/NAMPT_RAT NAMPT_RAT] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g9/2g95_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g95 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Phosphoribosyltransferase|Phosphoribosyltransferase]]
*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:016901503</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Nicotinamide phosphoribosyltransferase]]
[[Category: Rattus norvegicus]]
[[Category: Eom, S H.]]
[[Category: Kim, M K.]]
[[Category: Namprtase]]
[[Category: Pbef]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Transferase]]
[[Category: Eom SH]]
[[Category: Visfatin]]
[[Category: Kim M-K]]
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