1x45: Difference between revisions

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[[Image:1x45.gif|left|200px]]<br /><applet load="1x45" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1x45" />
'''Solution structure of the first PDZ domain of amyloid beta A4 precursor protein-binding family A, member 1'''<br />


==About this Structure==
==Solution structure of the first PDZ domain of amyloid beta A4 precursor protein-binding family A, member 1==
1X45 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X45 OCA].  
<StructureSection load='1x45' size='340' side='right'caption='[[1x45]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1x45]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X45 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X45 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x45 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x45 OCA], [https://pdbe.org/1x45 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x45 RCSB], [https://www.ebi.ac.uk/pdbsum/1x45 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x45 ProSAT], [https://www.topsan.org/Proteins/RSGI/1x45 TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/APBA1_HUMAN APBA1_HUMAN] Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x4/1x45_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x45 ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Hayashi, F.]]
[[Category: Hayashi F]]
[[Category: Qin, X R.]]
[[Category: Qin XR]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: adapter protein xii alpha]]
[[Category: amyloid beta a4 precursor protein-binding family a]]
[[Category: member 1]]
[[Category: national project on protein structural and functional analyses]]
[[Category: neuron-specific xii protein]]
[[Category: neuronal munc 18-1-interacting protein 1 mint-1]]
[[Category: nppsfa]]
[[Category: pdz domain]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomics]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:50:49 2008''
Retrieved from "https://proteopedia.org/1x45"