2q6o: Difference between revisions

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[[Image:2q6o.png|left|200px]]


{{STRUCTURE_2q6o|  PDB=2q6o  |  SCENE=  }}
==SalL-Y70T with SAM and Cl==
 
<StructureSection load='2q6o' size='340' side='right'caption='[[2q6o]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
===SalL-Y70T with SAM and Cl===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2q6o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salinispora_tropica_CNB-440 Salinispora tropica CNB-440]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q6O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q6O FirstGlance]. <br>
{{ABSTRACT_PUBMED_18059261}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q6o OCA], [https://pdbe.org/2q6o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q6o RCSB], [https://www.ebi.ac.uk/pdbsum/2q6o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q6o ProSAT]</span></td></tr>
[[2q6o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salinispora_tropica Salinispora tropica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q6O OCA].  
</table>
 
== Function ==
==Reference==
[https://www.uniprot.org/uniprot/SALL_SALTO SALL_SALTO] Involved in the biosynthesis of the proteosome inhibitor salinosporamide A (SalA). Catalyzes the halogenation of S-adenosyl-L-methionine (SAM) with chloride to generate 5'-chloro-5'-deoxyadenosine (5'-CIDA) and L-methionine. It can also use bromide and iodide, producing halogenated 5'-deoxyadenosine (5'-XDA) and L-methionine, however no halogenase activity is detected in the presence of fluoride.<ref>PMID:18059261</ref>
<ref group="xtra">PMID:018059261</ref><references group="xtra"/>
== Evolutionary Conservation ==
[[Category: Salinispora tropica]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: Noel, J P.]]
Check<jmol>
[[Category: Pojer, F.]]
  <jmolCheckbox>
[[Category: Biosynthetic protein]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q6/2q6o_consurf.spt"</scriptWhenChecked>
[[Category: Chlorinase]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Y70t mutant sam and cl complex]]
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q6o ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Salinispora tropica CNB-440]]
[[Category: Noel JP]]
[[Category: Pojer F]]
Retrieved from "https://proteopedia.org/2q6o"