2vb2: Difference between revisions

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[[Image:2vb2.png|left|200px]]


{{STRUCTURE_2vb2| PDB=2vb2 | SCENE= }}
==Crystal structure of Cu(I)CusF==
<StructureSection load='2vb2' size='340' side='right'caption='[[2vb2]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2vb2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_BL21(DE3) Escherichia coli BL21(DE3)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VB2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VB2 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vb2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vb2 OCA], [https://pdbe.org/2vb2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vb2 RCSB], [https://www.ebi.ac.uk/pdbsum/2vb2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vb2 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CUSF_ECOLI CUSF_ECOLI] Part of a cation efflux system that mediates resistance to copper and silver. Binds one copper per polypeptide.<ref>PMID:11399769</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vb/2vb2_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vb2 ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Methionine-rich motifs have an important role in copper trafficking factors, including the CusF protein. Here we show that CusF uses a new metal recognition site wherein Cu(I) is tetragonally displaced from a Met2His ligand plane toward a conserved tryptophan. Spectroscopic studies demonstrate that both thioether ligation and strong cation-pi interactions with tryptophan stabilize metal binding. This novel active site chemistry affords mechanisms for control of adventitious metal redox and substitution chemistry.


===CRYSTAL STRUCTURE OF CU(I)CUSF===
Cu(I) recognition via cation-pi and methionine interactions in CusF.,Xue Y, Davis AV, Balakrishnan G, Stasser JP, Staehlin BM, Focia P, Spiro TG, Penner-Hahn JE, O'Halloran TV Nat Chem Biol. 2008 Feb;4(2):107-9. Epub 2007 Dec 23. PMID:18157124<ref>PMID:18157124</ref>


{{ABSTRACT_PUBMED_18157124}}
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
==About this Structure==
<div class="pdbe-citations 2vb2" style="background-color:#fffaf0;"></div>
[[2vb2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VB2 OCA].
== References ==
 
<references/>
==Reference==
__TOC__
<ref group="xtra">PMID:018157124</ref><references group="xtra"/>
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Balakrishnan, G.]]
[[Category: Balakrishnan G]]
[[Category: Davis, A V.]]
[[Category: Davis AV]]
[[Category: Focia, P.]]
[[Category: Focia P]]
[[Category: Halloran, T V.O.]]
[[Category: O'Halloran TV]]
[[Category: Penner-Hahn, J E.]]
[[Category: Penner-Hahn JE]]
[[Category: Spiro, T G.]]
[[Category: Spiro TG]]
[[Category: Staehlin, B M.]]
[[Category: Staehlin BM]]
[[Category: Stasser, J P.]]
[[Category: Stasser JP]]
[[Category: Xue, Y.]]
[[Category: Xue Y]]
[[Category: Cation pi]]
[[Category: Copper tolerance]]
[[Category: Copper transport]]
[[Category: Metal transport]]
[[Category: Metal-binding]]

Latest revision as of 15:13, 13 December 2023

Crystal structure of Cu(I)CusF

2vb2, resolution 1.70Å

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