3c1y: Difference between revisions

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[[Image:3c1y.png|left|200px]]


{{STRUCTURE_3c1y|  PDB=3c1y  |  SCENE=  }}
==Structure of bacterial DNA damage sensor protein with co-purified and co-crystallized ligand==
 
<StructureSection load='3c1y' size='340' side='right'caption='[[3c1y]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
===Structure of bacterial DNA damage sensor protein with co-purified and co-crystallized ligand===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3c1y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C1Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C1Y FirstGlance]. <br>
{{ABSTRACT_PUBMED_18439896}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2BA:(2R,3R,3AS,5R,7AR,9R,10R,10AS,12R,14AR)-2,9-BIS(6-AMINO-9H-PURIN-9-YL)OCTAHYDRO-2H,7H-DIFURO[3,2-D 3,2-J][1,3,7,9,2,8]TETRAOXADIPHOSPHACYCLODODECINE-3,5,10,12-TETROL+5,12-DIOXIDE'>2BA</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c1y OCA], [https://pdbe.org/3c1y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c1y RCSB], [https://www.ebi.ac.uk/pdbsum/3c1y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c1y ProSAT]</span></td></tr>
[[3c1y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C1Y OCA].  
</table>
 
== Function ==
==Reference==
[https://www.uniprot.org/uniprot/DISA_THEMA DISA_THEMA] Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity).<ref>PMID:18439896</ref>   Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process. Does not convert GTP to c-di-GMP.<ref>PMID:18439896</ref>
<ref group="xtra">PMID:018439896</ref><references group="xtra"/>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c1/3c1y_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c1y ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
[[Category: Buttner, K.]]
[[Category: Buttner K]]
[[Category: Hartung, S.]]
[[Category: Hartung S]]
[[Category: Hopfner, K P.]]
[[Category: Hopfner KP]]
[[Category: Witte, G.]]
[[Category: Witte G]]
[[Category: Dna binding protein]]
[[Category: Dna damage]]
[[Category: Dna repair]]
[[Category: Dna-binding]]
Retrieved from "https://proteopedia.org/3c1y"