2wz9: Difference between revisions

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[[Image:2wz9.png|left|200px]]


{{STRUCTURE_2wz9|  PDB=2wz9  |  SCENE= }}
==Crystal structure of the thioredoxin domain of human TXNL2==
 
<StructureSection load='2wz9' size='340' side='right'caption='[[2wz9]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
===CRYSTAL STRUCTURE OF THE THIOREDOXIN DOMAIN OF HUMAN TXNL2===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2wz9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WZ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WZ9 FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wz9 OCA], [https://pdbe.org/2wz9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wz9 RCSB], [https://www.ebi.ac.uk/pdbsum/2wz9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wz9 ProSAT]</span></td></tr>
[[2wz9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WZ9 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/GLRX3_HUMAN GLRX3_HUMAN] Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wz/2wz9_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wz9 ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Large Structures]]
[[Category: Bountra, C.]]
[[Category: Arrowsmith CH]]
[[Category: Cocking, R.]]
[[Category: Bountra C]]
[[Category: Delft, F Von.]]
[[Category: Cocking R]]
[[Category: Edwards, A.]]
[[Category: Edwards A]]
[[Category: Johannson, C.]]
[[Category: Johannson C]]
[[Category: Kavanagh, K L.]]
[[Category: Kavanagh KL]]
[[Category: Muniz, J R.C.]]
[[Category: Muniz JRC]]
[[Category: Pike, A C.W.]]
[[Category: Pike ACW]]
[[Category: Vollmar, M.]]
[[Category: Vollmar M]]
[[Category: Weigelt, J.]]
[[Category: Weigelt J]]
[[Category: Protein binding]]
[[Category: Von Delft F]]
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