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[[Image:3dm5.png|left|200px]]


{{STRUCTURE_3dm5| PDB=3dm5 | SCENE= }}
==Structures of SRP54 and SRP19, the two proteins assembling the ribonucleic core of the Signal Recognition Particle from the archaeon Pyrococcus furiosus.==
<StructureSection load='3dm5' size='340' side='right'caption='[[3dm5]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3dm5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DM5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DM5 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.51&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dm5 OCA], [https://pdbe.org/3dm5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dm5 RCSB], [https://www.ebi.ac.uk/pdbsum/3dm5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dm5 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SRP54_PYRFU SRP54_PYRFU] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dm/3dm5_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dm5 ConSurf].
<div style="clear:both"></div>


===Structures of SRP54 and SRP19, the two proteins assembling the ribonucleic core of the Signal Recognition Particle from the archaeon Pyrococcus furiosus.===
==See Also==
 
*[[Signal recognition particle 3D structures|Signal recognition particle 3D structures]]
{{ABSTRACT_PUBMED_18953414}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
[[3dm5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DM5 OCA].
 
==Reference==
<ref group="xtra">PMID:018953414</ref><references group="xtra"/>
[[Category: Pyrococcus furiosus]]
[[Category: Pyrococcus furiosus]]
[[Category: Egea, P F.]]
[[Category: Egea PF]]
[[Category: Napetschnig, J.]]
[[Category: Napetschnig J]]
[[Category: Stroud, R M.]]
[[Category: Stroud RM]]
[[Category: Walter, P.]]
[[Category: Walter P]]
[[Category: Gtp-binding]]
[[Category: Nucleotide-binding]]
[[Category: Protein targeting]]
[[Category: Protein-rna]]
[[Category: Ribonucleoprotein]]
[[Category: Rna binding protein]]
[[Category: Rna-binding]]
[[Category: Signal recognition particle]]
[[Category: Srp-gtpase]]
[[Category: Transport protein]]
Retrieved from "https://proteopedia.org/3dm5"