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[[Image:2z1b.png|left|200px]]


{{STRUCTURE_2z1b|  PDB=2z1b  |  SCENE=  }}
==Crystal Structure of 5-aminolevulinic acid dehydratase (ALAD) from Mus musculs==
 
<StructureSection load='2z1b' size='340' side='right'caption='[[2z1b]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
===Crystal Structure of 5-aminolevulinic acid dehydratase (ALAD) from Mus musculs===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2z1b]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z1B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z1B FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z1b OCA], [https://pdbe.org/2z1b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z1b RCSB], [https://www.ebi.ac.uk/pdbsum/2z1b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z1b ProSAT], [https://www.topsan.org/Proteins/RSGI/2z1b TOPSAN]</span></td></tr>
[[2z1b]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z1B OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/HEM2_MOUSE HEM2_MOUSE] Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z1/2z1b_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2z1b ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Porphobilinogen synthase|Porphobilinogen synthase]]
*[[Porphobilinogen synthase|Porphobilinogen synthase]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Porphobilinogen synthase]]
[[Category: Kawazoe M]]
[[Category: Kawazoe, M.]]
[[Category: Kishishita S]]
[[Category: Kishishita, S.]]
[[Category: Murayama K]]
[[Category: Murayama, K.]]
[[Category: Shirozu M]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Takemoto C]]
[[Category: Shirozu, M.]]
[[Category: Terada T]]
[[Category: Takemoto, C.]]
[[Category: Wang H]]
[[Category: Terada, T.]]
[[Category: Xie Y]]
[[Category: Wang, H.]]
[[Category: Yokoyama S]]
[[Category: Xie, Y.]]
[[Category: Yokoyama, S.]]
[[Category: Conserved hypothetical protein]]
[[Category: Lyase]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Porphyrin biosynthesis]]
[[Category: Riken structural genomics/proteomics initiative]]
[[Category: Rsgi]]
[[Category: Structural genomic]]
[[Category: Structure genomic]]
Retrieved from "https://proteopedia.org/2z1b"