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[[Image:3afk.png|left|200px]]


{{STRUCTURE_3afk|  PDB=3afk  |  SCENE=  }}
==Crystal Structure of Agrocybe aegerita lectin AAL complexed with Thomsen-Friedenreich antigen==
 
<StructureSection load='3afk' size='340' side='right'caption='[[3afk]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
===Crystal Structure of Agrocybe aegerita lectin AAL complexed with Thomsen-Friedenreich antigen===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3afk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cyclocybe_aegerita Cyclocybe aegerita]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AFK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AFK FirstGlance]. <br>
{{ABSTRACT_PUBMED_20530247}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=PRD_900084:Thomsen-Friedenreich+antigen'>PRD_900084</scene>, <scene name='pdbligand=THR:THREONINE'>THR</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3afk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3afk OCA], [https://pdbe.org/3afk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3afk RCSB], [https://www.ebi.ac.uk/pdbsum/3afk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3afk ProSAT]</span></td></tr>
[[3afk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Agrocybe_aegerita Agrocybe aegerita]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AFK OCA].  
</table>
 
== Function ==
==Reference==
[https://www.uniprot.org/uniprot/ATLE_CYCAE ATLE_CYCAE] Anti-tumor lectin with DNase activity. Inhibits the growth of several tumor cell lines in vitro. Induces lymphocyte infiltration and necrosis of tumor cells in a mouse tumor model. Induces apoptosis in HeLa cells. Binds N-acetylneuraminyl lactose (N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucose) (PubMed:16051274).<ref>PMID:12757412</ref> <ref>PMID:16051274</ref>
<ref group="xtra">PMID:020530247</ref><references group="xtra"/>
== References ==
[[Category: Agrocybe aegerita]]
<references/>
[[Category: Feng, L.]]
__TOC__
[[Category: Li, D.]]
</StructureSection>
[[Category: Wang, D.]]
[[Category: Cyclocybe aegerita]]
[[Category: 3-galnac-alpha-o-thr]]
[[Category: Large Structures]]
[[Category: Aal]]
[[Category: Feng L]]
[[Category: Apoptosis]]
[[Category: Li D]]
[[Category: Gal-beta-1]]
[[Category: Wang D]]
[[Category: Galectin]]
[[Category: Hydrolase]]
[[Category: Lectin]]
[[Category: Nuclease]]
[[Category: Thomsen-friedenreich antigen]]

Latest revision as of 14:00, 13 March 2024

Crystal Structure of Agrocybe aegerita lectin AAL complexed with Thomsen-Friedenreich antigen

3afk, resolution 1.95Å

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