2r65: Difference between revisions

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[[Image:2r65.png|left|200px]]


{{STRUCTURE_2r65| PDB=2r65 | SCENE= }}
==Crystal structure of Helicobacter pylori ATP dependent protease, FtsH ADP complex==
<StructureSection load='2r65' size='340' side='right'caption='[[2r65]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2r65]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R65 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R65 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r65 OCA], [https://pdbe.org/2r65 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r65 RCSB], [https://www.ebi.ac.uk/pdbsum/2r65 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r65 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FTSH_HELPY FTSH_HELPY] Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity).[HAMAP-Rule:MF_01458]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r6/2r65_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r65 ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The ATP-dependent protease, FtsH, degrades misassembled membrane proteins for quality control like SecY, subunit a of FoF1-ATPase, and YccA, and digests short-lived soluble proteins in order to control their cellular regulation, including sigma32, LpxC and lambdacII. The FtsH protein has an N-terminal transmembrane segment and a large cytosolic region that consists of two domains, an ATPase and a protease domain. To provide a structural basis for the nucleotide-dependent domain motions and a better understanding of substrate translocation, the crystal structures of the Helicobacter pylori (Hp) FtsH ATPase domain in the nucleotide-free state and complexed with ADP, were determined. Two different structures of HpFtsH ATPase were observed, with the nucleotide-free state in an asymmetric unit, and these structures reveal the new forms and show other conformational differences between the nucleotide-free and ADP-bound state compared with previous structures. In particular, one HpFtsH Apo structure has a considerable rotation difference compared with the HpFtsH ADP complex, and this large conformational change reveals that FtsH may have the mechanical force needed for substrate translocation.


===Crystal structure of Helicobacter pylori ATP dependent protease, FtsH ADP complex===
Structural studies on Helicobacter pyloriATP-dependent protease, FtsH.,Kim SH, Kang GB, Song HE, Park SJ, Bea MH, Eom SH J Synchrotron Radiat. 2008 May;15(Pt 3):208-10. Epub 2008 Apr 18. PMID:18421140<ref>PMID:18421140</ref>


{{ABSTRACT_PUBMED_18421140}}
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
==About this Structure==
<div class="pdbe-citations 2r65" style="background-color:#fffaf0;"></div>
[[2r65]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R65 OCA].
== References ==
 
<references/>
==Reference==
__TOC__
<ref group="xtra">PMID:018421140</ref><references group="xtra"/>
</StructureSection>
[[Category: Helicobacter pylori]]
[[Category: Bae, M H.]]
[[Category: Eom, S H.]]
[[Category: Kang, G B.]]
[[Category: Kim, S H.]]
[[Category: Park, S J.]]
[[Category: Song, H E.]]
[[Category: Adp]]
[[Category: Atp-binding]]
[[Category: Atpase domain]]
[[Category: Cell cycle]]
[[Category: Cell division]]
[[Category: Ftsh]]
[[Category: Helicobacter pylori]]
[[Category: Helicobacter pylori]]
[[Category: Hydrolase]]
[[Category: Large Structures]]
[[Category: Membrane]]
[[Category: Bae M-H]]
[[Category: Metal-binding]]
[[Category: Eom SH]]
[[Category: Metalloprotease]]
[[Category: Kang GB]]
[[Category: Nucleotide-binding]]
[[Category: Kim SH]]
[[Category: Protease]]
[[Category: Park SJ]]
[[Category: Transmembrane]]
[[Category: Song H-E]]
Retrieved from "https://proteopedia.org/2r65"