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[[Image:2siv.png|left|200px]]


{{STRUCTURE_2siv| PDB=2siv | SCENE= }}
==SIV GP41 CORE STRUCTURE==
<StructureSection load='2siv' size='340' side='right'caption='[[2siv]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2siv]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Simian_immunodeficiency_virus Simian immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2SIV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2SIV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2siv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2siv OCA], [https://pdbe.org/2siv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2siv RCSB], [https://www.ebi.ac.uk/pdbsum/2siv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2siv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q8AKX0_SIV Q8AKX0_SIV]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/si/2siv_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2siv ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The gp41 subunit of the envelope protein complex from human and simian immunodeficiency viruses (HIV and SIV) mediates membrane fusion during viral entry. The crystal structure of the HIV-1 gp41 ectodomain core in its proposed fusion-active state is a six-helix bundle. Here we have reconstituted the core of the SIV gp41 ectodomain with two synthetic peptides called SIV N36 and SIV C34, which form a highly helical trimer of heterodimers. The 2.2 A resolution crystal structure of this SIV N36/C34 complex is very similar to the analogous structure in HIV-1 gp41. In both structures, three N36 helices form a central trimeric coiled coil. Three C34 helices pack in an antiparallel orientation into highly conserved, hydrophobic grooves along the surface of this coiled coil. The conserved nature of the N36-C34 interface suggests that the HIV-1 and SIV peptides are functionally interchangeable. Indeed, a heterotypic complex between HIV-1 N36 and SIV C34 peptides is highly helical and stable. Moreover, as with HIV-1 C34, the SIV C34 peptide is a potent inhibitor of HIV-1 infection. These results identify conserved packing interactions between the N and C helices of gp41 and have implications for the development of C peptide analogs with broad inhibitory activity.


===SIV GP41 CORE STRUCTURE===
Crystal structure of the simian immunodeficiency virus (SIV) gp41 core: conserved helical interactions underlie the broad inhibitory activity of gp41 peptides.,Malashkevich VN, Chan DC, Chutkowski CT, Kim PS Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9134-9. PMID:9689046<ref>PMID:9689046</ref>


{{ABSTRACT_PUBMED_9689046}}
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2siv" style="background-color:#fffaf0;"></div>


==About this Structure==
==See Also==
[[2siv]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Simian_immunodeficiency_virus Simian immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2SIV OCA].
*[[Gp41 3D Structures|Gp41 3D Structures]]
 
*[[Immunodeficiency virus protease 3D structures|Immunodeficiency virus protease 3D structures]]
==Reference==
== References ==
<ref group="xtra">PMID:009689046</ref><references group="xtra"/>
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Simian immunodeficiency virus]]
[[Category: Simian immunodeficiency virus]]
[[Category: Chan, D C.]]
[[Category: Chan DC]]
[[Category: Chutkowski, C T.]]
[[Category: Chutkowski CT]]
[[Category: Kim, P S.]]
[[Category: Kim PS]]
[[Category: Malashkevich, V N.]]
[[Category: Malashkevich VN]]
[[Category: Coat protein]]
[[Category: Envelope glycoprotein]]
[[Category: Gp41]]
[[Category: Hiv]]
[[Category: Retrovirus]]
[[Category: Siv]]
Retrieved from "https://proteopedia.org/2siv"