2rqu: Difference between revisions

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[[Image:2rqu.png|left|200px]]


{{STRUCTURE_2rqu|  PDB=2rqu  |  SCENE=  }}
==Solution structure of the complex between the DDEF1 SH3 domain and the APC SAMP1 motif==
 
<StructureSection load='2rqu' size='340' side='right'caption='[[2rqu]]' scene=''>
===Solution structure of the complex between the DDEF1 SH3 domain and the APC SAMP1 motif===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2rqu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RQU FirstGlance]. <br>
{{ABSTRACT_PUBMED_20509626}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rqu OCA], [https://pdbe.org/2rqu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rqu RCSB], [https://www.ebi.ac.uk/pdbsum/2rqu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rqu ProSAT]</span></td></tr>
==About this Structure==
</table>
[[2rqu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQU OCA].  
== Function ==
 
[https://www.uniprot.org/uniprot/ASAP1_HUMAN ASAP1_HUMAN] Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types (By similarity). Plays a role in ciliogenesis.<ref>PMID:20393563</ref>  
==Reference==
== Evolutionary Conservation ==
<ref group="xtra">PMID:020509626</ref><references group="xtra"/>
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rq/2rqu_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rqu ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Ikegami, T.]]
[[Category: Large Structures]]
[[Category: Kaieda, S.]]
[[Category: Ikegami T]]
[[Category: Matsui, C.]]
[[Category: Kaieda S]]
[[Category: Mimori-Kiyosue, Y.]]
[[Category: Matsui C]]
[[Category: Cell junction]]
[[Category: Mimori-Kiyosue Y]]
[[Category: Disease mutation]]
[[Category: Gap]]
[[Category: Phosphoprotein]]
[[Category: Samp motif]]
[[Category: Sh3 domain]]
[[Category: Signaling protein]]
[[Category: Tumor suppressor]]
[[Category: Wnt signaling pathway]]
Retrieved from "https://proteopedia.org/2rqu"