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[[Image:2vzn.png|left|200px]]


{{STRUCTURE_2vzn| PDB=2vzn | SCENE= }}
==Crystal structure of the major allergen from fire ant venom, Sol i 3==
<StructureSection load='2vzn' size='340' side='right'caption='[[2vzn]], [[Resolution|resolution]] 3.05&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2vzn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Solenopsis_invicta Solenopsis invicta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VZN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VZN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.05&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vzn OCA], [https://pdbe.org/2vzn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vzn RCSB], [https://www.ebi.ac.uk/pdbsum/2vzn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vzn ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VA3_SOLIN VA3_SOLIN]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vz/2vzn_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vzn ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Fire ant venom is an extremely potent allergy-inducing agent containing four major allergens, Sol i 1 to Sol i 4, which are the most frequent cause of hypersensitivity reactions to hymenoptera in the southern USA. The crystal structure of recombinant (Baculovirus) major fire ant allergen Sol i 3 has been determined to a resolution of 3.1 A by the method of molecular replacement. The secondary-structure elements of Sol i 3 are arranged in an alpha-beta-alpha sandwich fold consisting of a central antiparallel beta-sheet surrounded on both sides by alpha helices. The overall structure is very similar to that of the homologous wasp venom allergen Ves v 5 with major differences occurring in the solvent-exposed loop regions that contain amino acid insertions. Consequently, the limited conservation of surface chemical properties and topology between Sol i 3 and Ves v 5 may explain the observed lack of relevant cross-reactivity. It is concluded that Sol i 3 recognizes immunoglobulin E antibodies with a distinct set of its own epitopes, which are different from those of Ves v 5. Indeed, the molecular area in Sol i 3 covered by non-conserved residues is large enough to accommodate four unique Sol i 3 epitopes.


===CRYSTAL STRUCTURE OF THE MAJOR ALLERGEN FROM FIRE ANT VENOM, SOL I 3===
Crystal structure of the major allergen from fire ant venom, Sol i 3.,Padavattan S, Schmidt M, Hoffman DR, Markovic-Housley Z J Mol Biol. 2008 Oct 31;383(1):178-85. Epub 2008 Aug 22. PMID:18761353<ref>PMID:18761353</ref>


{{ABSTRACT_PUBMED_18761353}}
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
==About this Structure==
<div class="pdbe-citations 2vzn" style="background-color:#fffaf0;"></div>
[[2vzn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Solenopsis_invicta Solenopsis invicta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VZN OCA].
== References ==
 
<references/>
==Reference==
__TOC__
<ref group="xtra">PMID:018761353</ref><references group="xtra"/>
</StructureSection>
[[Category: Large Structures]]
[[Category: Solenopsis invicta]]
[[Category: Solenopsis invicta]]
[[Category: Markovic-Housley, Z.]]
[[Category: Markovic-Housley Z]]
[[Category: Padavattan, S.]]
[[Category: Padavattan S]]
[[Category: Allergen]]
[[Category: Cross-reactivity]]
[[Category: Major fire ant allergen]]
[[Category: Secreted]]
[[Category: Sol i 3]]
Retrieved from "https://proteopedia.org/2vzn"