3ckf: Difference between revisions

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[[Image:3ckf.png|left|200px]]


{{STRUCTURE_3ckf| PDB=3ckf | SCENE= }}
==The crystal structure of OspA deletion mutant==
<StructureSection load='3ckf' size='340' side='right'caption='[[3ckf]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3ckf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Borreliella_burgdorferi Borreliella burgdorferi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CKF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ckf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ckf OCA], [https://pdbe.org/3ckf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ckf RCSB], [https://www.ebi.ac.uk/pdbsum/3ckf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ckf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q45040_BORBG Q45040_BORBG]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ck/3ckf_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ckf ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Recent studies suggest the dominant role of main-chain H-bond formation in specifying beta-sheet topology. Its essentially sequence-independent nature implies a large degree of freedom in designing beta-sheet-based nanomaterials. Here we show rational design of beta-sheet face inversions by incremental deletions of beta-strands from the single-layer beta-sheet of Borrelia outer surface protein A. We show that a beta-sheet structure can be maintained when a large number of native contacts are removed and that one can design large-scale conformational transitions of a beta-sheet such as face inversion by exploiting the promiscuity of strand-strand interactions. High-resolution X-ray crystal structures confirmed the success of the design and supported the importance of main-chain H-bonds in determining beta-sheet topology. This work suggests a simple but effective strategy for designing and controlling nanomaterials based on beta-rich peptide self-assemblies.


===The crystal structure of OspA deletion mutant===
The promiscuity of beta-strand pairing allows for rational design of beta-sheet face inversion.,Makabe K, Koide S J Am Chem Soc. 2008 Nov 5;130(44):14370-1. Epub 2008 Oct 9. PMID:18842042<ref>PMID:18842042</ref>


{{ABSTRACT_PUBMED_18842042}}
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3ckf" style="background-color:#fffaf0;"></div>


==About this Structure==
==See Also==
[[3ckf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Borrelia_burgdorferi Borrelia burgdorferi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CKF OCA].
*[[Outer surface protein|Outer surface protein]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:018842042</ref><references group="xtra"/>
__TOC__
[[Category: Borrelia burgdorferi]]
</StructureSection>
[[Category: Koide, S.]]
[[Category: Borreliella burgdorferi]]
[[Category: Makabe, K.]]
[[Category: Large Structures]]
[[Category: Beta-sheet]]
[[Category: Koide S]]
[[Category: Membrane protein]]
[[Category: Makabe K]]
Retrieved from "https://proteopedia.org/3ckf"