3d32: Difference between revisions

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[[Image:3d32.png|left|200px]]


{{STRUCTURE_3d32| PDB=3d32 | SCENE= }}
==Complex of GABA(A) receptor-associated protein (GABARAP) with a synthetic peptide==
<StructureSection load='3d32' size='340' side='right'caption='[[3d32]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3d32]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D32 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D32 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d32 OCA], [https://pdbe.org/3d32 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d32 RCSB], [https://www.ebi.ac.uk/pdbsum/3d32 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d32 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GBRAP_HUMAN GBRAP_HUMAN] May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy (By similarity).<ref>PMID:15977068</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d3/3d32_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3d32 ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The gamma-aminobutyric acid type A (GABA(A)) receptor-associated protein is a versatile adaptor protein playing an important role in intracellular vesicle trafficking, particularly in neuronal cells. We present the X-ray structure of the soluble form of human GABA(A) receptor-associated protein complexed with a high-affinity synthetic peptide at 1.3 A resolution. The data shed light on the probable binding modes of key interaction partners, including the GABA(A) receptor and the cysteine protease Atg4. The resulting models provide a structural background for further investigation of the unique biological properties of this protein.


===Complex of GABA(A) receptor-associated protein (GABARAP) with a synthetic peptide===
Ligand binding mode of GABAA receptor-associated protein.,Weiergraber OH, Stangler T, Thielmann Y, Mohrluder J, Wiesehan K, Willbold D J Mol Biol. 2008 Sep 19;381(5):1320-31. Epub 2008 Jul 7. PMID:18638487<ref>PMID:18638487</ref>


{{ABSTRACT_PUBMED_18638487}}
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3d32" style="background-color:#fffaf0;"></div>


==About this Structure==
==See Also==
[[3d32]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D32 OCA].
*[[GABA receptor-associated protein 3D structures|GABA receptor-associated protein 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:018638487</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Stangler, T.]]
[[Category: Large Structures]]
[[Category: Weiergraeber, O H.]]
[[Category: Synthetic construct]]
[[Category: Willbold, D.]]
[[Category: Stangler T]]
[[Category: Alpha-beta]]
[[Category: Weiergraeber OH]]
[[Category: Beta-grasp fold]]
[[Category: Willbold D]]
[[Category: Cytoskeleton]]
[[Category: Golgi apparatus]]
[[Category: Membrane]]
[[Category: Microtubule]]
[[Category: Transport]]
[[Category: Transport protein]]
Retrieved from "https://proteopedia.org/3d32"