2wde: Difference between revisions

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[[Image:2wde.png|left|200px]]


{{STRUCTURE_2wde| PDB=2wde | SCENE= }}
==Termus thermophilus Sulfate thiohydrolase SoxB in complex with thiosulfate==
<StructureSection load='2wde' size='340' side='right'caption='[[2wde]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2wde]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB27 Thermus thermophilus HB27]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WDE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WDE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=TBU:TERTIARY-BUTYL+ALCOHOL'>TBU</scene>, <scene name='pdbligand=THJ:THIOSULFATE'>THJ</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wde FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wde OCA], [https://pdbe.org/2wde PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wde RCSB], [https://www.ebi.ac.uk/pdbsum/2wde PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wde ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q72IT0_THET2 Q72IT0_THET2]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wd/2wde_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wde ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
SoxB is an essential component of the bacterial Sox sulfur oxidation pathway. SoxB contains a di-manganese(II) site and is proposed to catalyze the release of sulfate from a protein-bound cysteine S-thiosulfonate. A direct assay for SoxB activity is described. The structure of recombinant Thermus thermophilus SoxB was determined by x-ray crystallography to a resolution of 1.5 A. Structures were also determined for SoxB in complex with the substrate analogue thiosulfate and in complex with the product sulfate. A mechanistic model for SoxB is proposed based on these structures.


===TERMUS THERMOPHILUS SULFATE THIOHYDROLASE SOXB IN COMPLEX WITH THIOSULFATE===
Mechanism for the hydrolysis of a sulfur-sulfur bond based on the crystal structure of the thiosulfohydrolase SoxB.,Sauve V, Roversi P, Leath KJ, Garman EF, Antrobus R, Lea SM, Berks BC J Biol Chem. 2009 Aug 7;284(32):21707-18. Epub 2009 Jun 16. PMID:19535341<ref>PMID:19535341</ref>


{{ABSTRACT_PUBMED_19535341}}
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
==About this Structure==
<div class="pdbe-citations 2wde" style="background-color:#fffaf0;"></div>
[[2wde]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WDE OCA].
== References ==
 
<references/>
==Reference==
__TOC__
<ref group="xtra">PMID:019535341</ref><references group="xtra"/>
</StructureSection>
[[Category: Hydrolase]]
[[Category: Large Structures]]
[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus HB27]]
[[Category: Antrobus, R.]]
[[Category: Antrobus R]]
[[Category: Berks, B C.]]
[[Category: Berks BC]]
[[Category: Garman, E F.]]
[[Category: Garman EF]]
[[Category: Lea, S M.]]
[[Category: Lea SM]]
[[Category: Leath, K J.]]
[[Category: Leath KJ]]
[[Category: Roversi, P.]]
[[Category: Roversi P]]
[[Category: Sauve, V.]]
[[Category: Sauve V]]
[[Category: Cys s-thiosulfonate]]
[[Category: Hydrolase]]
[[Category: Sox]]
[[Category: Soxb]]
[[Category: Sulfur oxidation pathway]]
[[Category: Sulfur-sulfur hydrolysis]]

Latest revision as of 15:52, 13 December 2023

Termus thermophilus Sulfate thiohydrolase SoxB in complex with thiosulfate

2wde, resolution 1.85Å

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