3bej: Difference between revisions

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[[Image:3bej.png|left|200px]]


{{STRUCTURE_3bej| PDB=3bej | SCENE= }}
==Structure of human FXR in complex with MFA-1 and co-activator peptide==
<StructureSection load='3bej' size='340' side='right'caption='[[3bej]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3bej]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BEJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BEJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MUF:(8ALPHA,10ALPHA,13ALPHA,17BETA)-17-[(4-HYDROXYPHENYL)CARBONYL]ANDROSTA-3,5-DIENE-3-CARBOXYLIC+ACID'>MUF</scene>, <scene name='pdbligand=YT3:YTTRIUM+(III)+ION'>YT3</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bej OCA], [https://pdbe.org/3bej PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bej RCSB], [https://www.ebi.ac.uk/pdbsum/3bej PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bej ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/be/3bej_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bej ConSurf].
<div style="clear:both"></div>


===Structure of human FXR in complex with MFA-1 and co-activator peptide===
==See Also==
 
*[[Bile acid receptor 3D structures|Bile acid receptor 3D structures]]
{{ABSTRACT_PUBMED_18391212}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[3bej]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BEJ OCA].
</StructureSection>
 
==Reference==
<ref group="xtra">PMID:018391212</ref><references group="xtra"/>
[[Category: Histone acetyltransferase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Becker, J W.]]
[[Category: Large Structures]]
[[Category: Parthasarathy, G]]
[[Category: Becker JW]]
[[Category: Soisson, S M.]]
[[Category: Parthasarathy G]]
[[Category: Activator]]
[[Category: Soisson SM]]
[[Category: Acyltransferase]]
[[Category: Bar]]
[[Category: Bile acid receptor]]
[[Category: Dna-binding]]
[[Category: Fxr]]
[[Category: Metal-binding]]
[[Category: Nhr]]
[[Category: Nr1h4]]
[[Category: Nuclear receptor]]
[[Category: Nucleus]]
[[Category: Phosphoprotein]]
[[Category: Proto-oncogene]]
[[Category: Repressor]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Transcription regulator]]
[[Category: Transcription-transferase complex]]
[[Category: Transferase]]
[[Category: Zinc-finger]]
Retrieved from "https://proteopedia.org/3bej"