4ijd: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 4ijd is ~~ON HOLD~~

==Crystal structure of methyltransferase domain of human PR domain-containing protein 9==

== Structural highlights ==

<table><tr><td colspan='2'>[[4ijd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IJD OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=4IJD FirstGlance].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=4ijd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ijd OCA], [https://pdbe.org/4ijd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ijd RCSB], [https://www.ebi.ac.uk/pdbsum/4ijd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ijd ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/PRDM9_HUMAN PRDM9_HUMAN] Histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 during meiotic prophase and is essential for proper meiotic progression. Does not have the ability to mono- and dimethylate 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes during early meiotic prophase (By similarity).

~~Authors~~: Dong, A~~., Dombrovski, L.,~~ Li, Y., Tempel, W~~., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J.,~~ Wu, H~~., Structural Genomics Consortium (SGC)~~

==See Also==

*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]

~~Description: Crystal structure of methyltransferase domain of human PR domain-containing protein 9~~

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Arrowsmith CH]]

[[Category: Bountra C]]

[[Category: Brown PJ]]

[[Category: Dombrovski L]]

[[Category: Dong A]]

[[Category: Edwards AM]]

[[Category: Li Y]]

[[Category: Tempel W]]

[[Category: Wu H]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4ijd is ON HOLD
+==Crystal structure of methyltransferase domain of human PR domain-containing protein 9==
+<StructureSection load='4ijd' size='340' side='right'caption='[[4ijd]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4ijd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IJD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IJD FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ijd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ijd OCA], [https://pdbe.org/4ijd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ijd RCSB], [https://www.ebi.ac.uk/pdbsum/4ijd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ijd ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PRDM9_HUMAN PRDM9_HUMAN] Histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 during meiotic prophase and is essential for proper meiotic progression. Does not have the ability to mono- and dimethylate 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes during early meiotic prophase (By similarity).
-Authors: Dong, A., Dombrovski, L., Li, Y., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Wu, H., Structural Genomics Consortium (SGC)
+==See Also==
+*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
-Description: Crystal structure of methyltransferase domain of human PR domain-containing protein 9
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Arrowsmith CH]]
+[[Category: Bountra C]]
+[[Category: Brown PJ]]
+[[Category: Dombrovski L]]
+[[Category: Dong A]]
+[[Category: Edwards AM]]
+[[Category: Li Y]]
+[[Category: Tempel W]]
+[[Category: Wu H]]