4dx8: Difference between revisions
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==ICAP1 in complex with KRIT1 N-terminus== | |||
<StructureSection load='4dx8' size='340' side='right'caption='[[4dx8]], [[Resolution|resolution]] 2.54Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4dx8]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DX8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DX8 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.54Å</td></tr> | |||
== | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr> | ||
[[4dx8]] is a 8 chain structure with sequence from [ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dx8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dx8 OCA], [https://pdbe.org/4dx8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dx8 RCSB], [https://www.ebi.ac.uk/pdbsum/4dx8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dx8 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ITBP1_HUMAN ITBP1_HUMAN] Regulates integrin signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. May play a role in the recruitment of ITGB1 to focal contacts during integrin-dependent cell adhesion.[REFERENCE:8] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Boggon | [[Category: Large Structures]] | ||
[[Category: Calderwood | [[Category: Boggon TJ]] | ||
[[Category: Draheim | [[Category: Calderwood DA]] | ||
[[Category: Liu | [[Category: Draheim K]] | ||
[[Category: Zhang | [[Category: Liu W]] | ||
[[Category: Zhang R]] | |||
Latest revision as of 10:59, 1 March 2024
ICAP1 in complex with KRIT1 N-terminus
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