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[[Image:3eei.png|left|200px]]


{{STRUCTURE_3eei|  PDB=3eei  |  SCENE=  }}
==Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from neisseria meningitidis in complex with methylthio-immucillin-A==
 
<StructureSection load='3eei' size='340' side='right'caption='[[3eei]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
===Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from neisseria meningitidis in complex with methylthio-immucillin-A===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3eei]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_meningitidis_serogroup_B Neisseria meningitidis serogroup B]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EEI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EEI FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.78&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MTM:(3S,4R)-2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-[(METHYLSULFANYL)METHYL]PYRROLIDINE-3,4-DIOL'>MTM</scene></td></tr>
[[3eei]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Neisseria_meningitidis_serogroup_b Neisseria meningitidis serogroup b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EEI OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eei OCA], [https://pdbe.org/3eei PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eei RCSB], [https://www.ebi.ac.uk/pdbsum/3eei PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eei ProSAT]</span></td></tr>
[[Category: Neisseria meningitidis serogroup b]]
</table>
[[Category: Almo, S C.]]
== Function ==
[[Category: Brown, R L.]]
[https://www.uniprot.org/uniprot/Q9K054_NEIMB Q9K054_NEIMB] Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.[HAMAP-Rule:MF_01684][SAAS:SAAS00035153]
[[Category: Furneaux, R H.]]
== Evolutionary Conservation ==
[[Category: Ho, M.]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: Norris, G E.]]
Check<jmol>
[[Category: Rinaldo-matthis, A.]]
  <jmolCheckbox>
[[Category: Schramm, V L.]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ee/3eei_consurf.spt"</scriptWhenChecked>
[[Category: Tyler, P C.]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidase]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Glycosidase]]
  </jmolCheckbox>
[[Category: Hydrolase]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3eei ConSurf].
[[Category: Immucillin some]]
<div style="clear:both"></div>
[[Category: Mtan]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Neisseria meningitidis serogroup B]]
[[Category: Almo SC]]
[[Category: Brown RL]]
[[Category: Furneaux RH]]
[[Category: Ho M]]
[[Category: Norris GE]]
[[Category: Rinaldo-matthis A]]
[[Category: Schramm VL]]
[[Category: Tyler PC]]
Retrieved from "https://proteopedia.org/3eei"