3w4j: Difference between revisions
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==Crystal Structure of human DAAO in complex with coumpound 12== | |||
<StructureSection load='3w4j' size='340' side='right'caption='[[3w4j]], [[Resolution|resolution]] 2.74Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3w4j]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W4J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W4J FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.74Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2LD:3-HYDROXY-5-(2-PHENYLETHYL)PYRIDIN-2(1H)-ONE'>2LD</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w4j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w4j OCA], [https://pdbe.org/3w4j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w4j RCSB], [https://www.ebi.ac.uk/pdbsum/3w4j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w4j ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/OXDA_HUMAN OXDA_HUMAN] Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.<ref>PMID:17303072</ref> | |||
==See Also== | |||
*[[Amino acid oxidase 3D structures|Amino acid oxidase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Hamajima T]] | |||
[[Category: Harada K]] | |||
[[Category: Hondo T]] | |||
[[Category: Matsumoto Y]] | |||
[[Category: Nakanishi K]] | |||
[[Category: Namatame I]] | |||
[[Category: Niimi T]] | |||
[[Category: Orita M]] | |||
[[Category: Sakashita H]] | |||
[[Category: Takeuchi M]] | |||
[[Category: Warizaya M]] | |||
[[Category: Watanabe T]] | |||
[[Category: Yamaguchi T]] | |||
Latest revision as of 08:43, 20 March 2024
Crystal Structure of human DAAO in complex with coumpound 12
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