4fqo: Difference between revisions
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==Crystal Structure of Calcium-Loaded S100B Bound to SBi4211== | |||
<StructureSection load='4fqo' size='340' side='right'caption='[[4fqo]], [[Resolution|resolution]] 1.65Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4fqo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FQO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FQO FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZ3:4,4-[HEPTANE-1,7-DIYLBIS(OXY)]DIBENZENECARBOXIMIDAMIDE'>AZ3</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fqo OCA], [https://pdbe.org/4fqo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fqo RCSB], [https://www.ebi.ac.uk/pdbsum/4fqo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fqo ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/S100B_BOVIN S100B_BOVIN] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization (By similarity).<ref>PMID:14661952</ref> | |||
== | ==See Also== | ||
*[[S100 proteins 3D structures|S100 proteins 3D structures]] | |||
== References == | |||
<references/> | |||
== | __TOC__ | ||
</StructureSection> | |||
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: Bezawada | [[Category: Large Structures]] | ||
[[Category: Coop | [[Category: Bezawada P]] | ||
[[Category: Hartman | [[Category: Coop A]] | ||
[[Category: Kudrimoti | [[Category: Hartman KG]] | ||
[[Category: MacKerrell | [[Category: Kudrimoti S]] | ||
[[Category: McKnight | [[Category: MacKerrell AD]] | ||
[[Category: Raman | [[Category: McKnight LE]] | ||
[[Category: Toth | [[Category: Raman EP]] | ||
[[Category: Weber | [[Category: Toth EA]] | ||
[[Category: Wilder | [[Category: Weber DJ]] | ||
[[Category: Wilder PT]] | |||
Latest revision as of 11:23, 1 March 2024
Crystal Structure of Calcium-Loaded S100B Bound to SBi4211
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