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[[Image:3jue.png|left|200px]]


{{STRUCTURE_3jue|  PDB=3jue  |  SCENE=  }}
==Crystal Structure of ArfGAP and ANK repeat domain of ACAP1==
 
<StructureSection load='3jue' size='340' side='right'caption='[[3jue]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
===Crystal Structure of ArfGAP and ANK repeat domain of ACAP1===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3jue]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JUE FirstGlance]. <br>
{{ABSTRACT_PUBMED_22645133}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jue FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jue OCA], [https://pdbe.org/3jue PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jue RCSB], [https://www.ebi.ac.uk/pdbsum/3jue PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jue ProSAT]</span></td></tr>
[[3jue]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUE OCA].  
</table>
 
== Function ==
==Reference==
[https://www.uniprot.org/uniprot/ACAP1_HUMAN ACAP1_HUMAN] GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.<ref>PMID:11062263</ref> <ref>PMID:16256741</ref> <ref>PMID:17398097</ref> <ref>PMID:17664335</ref> <ref>PMID:22645133</ref>
<ref group="xtra">PMID:022645133</ref><references group="xtra"/>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ju/3jue_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jue ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Ma, J.]]
[[Category: Large Structures]]
[[Category: Pang, X.]]
[[Category: Ma J]]
[[Category: Sun, F.]]
[[Category: Pang X]]
[[Category: Zhang, K.]]
[[Category: Sun F]]
[[Category: Zhou, Q.]]
[[Category: Zhang K]]
[[Category: Ank repeat]]
[[Category: Zhou Q]]
[[Category: Arfgap domain]]
[[Category: Gtpase activation]]
[[Category: Metal-binding]]
[[Category: Nitration]]
[[Category: Phosphoprotein]]
[[Category: Protein transport]]
[[Category: Protein transport-endocytosis complex]]
[[Category: Transport]]
[[Category: Zinc-binding module]]
[[Category: Zinc-finger]]
Retrieved from "https://proteopedia.org/3jue"