3ux4: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| (3 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==Crystal structure of the urea channel from the human gastric pathogen Helicobacter pylori== | |||
<StructureSection load='3ux4' size='340' side='right'caption='[[3ux4]], [[Resolution|resolution]] 3.26Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3ux4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori_J99 Helicobacter pylori J99]. The February 2013 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Proton-Gated Urea Channel'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2013_2 10.2210/rcsb_pdb/mom_2013_2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UX4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UX4 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.26Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XP4:1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHATE'>XP4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ux4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ux4 OCA], [https://pdbe.org/3ux4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ux4 RCSB], [https://www.ebi.ac.uk/pdbsum/3ux4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ux4 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/UREI_HELPJ UREI_HELPJ] Functions as a specific, H(+)-activated urea channel that increases the rate of urea entry into the cytoplasm, resulting in activation of cytoplasmic urease at acidic medium pH. Is essential for H.pylori gastric survival and colonization. Is necessary for the adaptation of urease activity to the extracellular pH, as in the presence of urea, UreI rapidly enhances the production of ammonia in the extracellular medium when the pH of the medium was decreased to pH5 or below (By similarity). | |||
== | ==See Also== | ||
*[[Urease accessory protein|Urease accessory protein]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Helicobacter pylori J99]] | |||
[[ | [[Category: Large Structures]] | ||
[[Category: | [[Category: Proton-Gated Urea Channel]] | ||
[[Category: | [[Category: RCSB PDB Molecule of the Month]] | ||
[[Category: | [[Category: Luecke H]] | ||
[[Category: | [[Category: McNulty R]] | ||
Latest revision as of 10:29, 1 March 2024
Crystal structure of the urea channel from the human gastric pathogen Helicobacter pylori
| ||||||||||||
