1tmm: Difference between revisions

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[[Image:1tmm.png|left|200px]]


{{STRUCTURE_1tmm| PDB=1tmm | SCENE= }}
==Crystal structure of ternary complex of E.coli HPPK(W89A) with MGAMPCPP and 6-Hydroxymethylpterin==
<StructureSection load='1tmm' size='340' side='right'caption='[[1tmm]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1tmm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TMM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TMM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=APC:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>APC</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HHR:6-HYDROXYMETHYLPTERIN'>HHR</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tmm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tmm OCA], [https://pdbe.org/1tmm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tmm RCSB], [https://www.ebi.ac.uk/pdbsum/1tmm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tmm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HPPK_ECOLI HPPK_ECOLI]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tm/1tmm_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tmm ConSurf].
<div style="clear:both"></div>


===Crystal structure of ternary complex of E.coli HPPK(W89A) with MGAMPCPP and 6-Hydroxymethylpterin===
==See Also==
 
*[[HPPK 3D structures|HPPK 3D structures]]
{{ABSTRACT_PUBMED_15952765}}
__TOC__
 
</StructureSection>
==About this Structure==
[[1tmm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TMM OCA].
 
==Reference==
<ref group="xtra">PMID:015952765</ref><ref group="xtra">PMID:010378268</ref><references group="xtra"/>
[[Category: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Blaszczyk, J.]]
[[Category: Large Structures]]
[[Category: Ji, X.]]
[[Category: Blaszczyk J]]
[[Category: Li, Y.]]
[[Category: Ji X]]
[[Category: Shi, G.]]
[[Category: Li Y]]
[[Category: Wu, Y.]]
[[Category: Shi G]]
[[Category: Yan, H.]]
[[Category: Wu Y]]
[[Category: 6-hydroxymethyl-7]]
[[Category: Yan H]]
[[Category: 6-hydroxymethylpterin]]
[[Category: 8-dihydropterin]]
[[Category: Antimicrobial agent]]
[[Category: Catalytic mechanism]]
[[Category: Drug design]]
[[Category: Folate]]
[[Category: Hppk]]
[[Category: Product release]]
[[Category: Pterin]]
[[Category: Pyrophosphokinase]]
[[Category: Pyrophosphoryl transfer]]
[[Category: Substrate specificity]]
[[Category: Ternary complex]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/1tmm"