4b2k: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| (5 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==COMPLEXES OF DODECIN WITH FLAVIN AND FLAVIN-LIKE LIGANDS== | |||
<StructureSection load='4b2k' size='340' side='right'caption='[[4b2k]], [[Resolution|resolution]] 1.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4b2k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Halobacterium_salinarum_R1 Halobacterium salinarum R1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B2K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B2K FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4IN:4-AMINO-L-TRYPTOPHAN'>4IN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RBF:RIBOFLAVIN'>RBF</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b2k OCA], [https://pdbe.org/4b2k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b2k RCSB], [https://www.ebi.ac.uk/pdbsum/4b2k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b2k ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DODEC_HALS3 DODEC_HALS3] May function as storage protein that sequesters riboflavin and related compounds, thereby protecting the cell against undesirable reactions mediated by the free flavins. Binds and sequesters riboflavin, lumiflavin and lumichrome. Can also bind FAD and FMN (in vitro), but has low affinity for FAD and even lower affinity for FMN. Protects bound flavins against light damage; Trp-36 rapidly quenches the flavin excited state. Promotes the conversion of bound riboflavin to lumichrome.<ref>PMID:12679016</ref> <ref>PMID:16460756</ref> <ref>PMID:17027852</ref> <ref>PMID:19224924</ref> <ref>PMID:20408700</ref> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Tamed electrons: To manipulate a protein photocycle in a directed manner, the flavoprotein dodecin was endoscopically modified at its key amino acid tryptophan with substituents carefully selected by their structural and electronic influence. The approach is ideal in the precision of rational protein engineering, and allows correlating tryptophan ionization potentials and electron transfer rates in a Marcus model. | |||
Directed Manipulation of a Flavoprotein Photocycle.,Staudt H, Hoesl MG, Dreuw A, Serdjukow S, Oesterhelt D, Budisa N, Wachtveitl J, Grininger M Angew Chem Int Ed Engl. 2013 Jul 1. doi: 10.1002/anie.201302334. PMID:23818044<ref>PMID:23818044</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 4b2k" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Halobacterium salinarum R1]] | |||
[[Category: Large Structures]] | |||
[[Category: Budisa N]] | |||
[[Category: Dreuw A]] | |||
[[Category: Grininger M]] | |||
[[Category: Hoesl M]] | |||
[[Category: Oesterhelt D]] | |||
[[Category: Serdjukow S]] | |||
[[Category: Staudt H]] | |||
[[Category: Wachtveitl J]] | |||
Latest revision as of 11:41, 20 December 2023
COMPLEXES OF DODECIN WITH FLAVIN AND FLAVIN-LIKE LIGANDS
| ||||||||||||
