4g3f: Difference between revisions
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==Crystal structure of murine NF-kappaB inducing kinase (NIK) bound to a 2-(aminothiazoly)phenol (cmp2)== | |||
<StructureSection load='4g3f' size='340' side='right'caption='[[4g3f]], [[Resolution|resolution]] 1.64Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4g3f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G3F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G3F FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.642Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0WB:3-{2-[(5-FLUORO-2-HYDROXYPHENYL)AMINO]-1,3-THIAZOL-4-YL}BENZONITRILE'>0WB</scene></td></tr> | |||
== | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g3f OCA], [https://pdbe.org/4g3f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g3f RCSB], [https://www.ebi.ac.uk/pdbsum/4g3f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g3f ProSAT]</span></td></tr> | ||
[[4g3f]] is a 1 chain structure with sequence from [ | </table> | ||
[[ | == Function == | ||
[https://www.uniprot.org/uniprot/M3K14_MOUSE M3K14_MOUSE] Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner.<ref>PMID:11239468</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Hymowitz SG]] | |||
[[Category: Hymowitz | [[Category: De Leon-Boenig G]] | ||
[[Category: | |||
Latest revision as of 11:25, 1 March 2024
Crystal structure of murine NF-kappaB inducing kinase (NIK) bound to a 2-(aminothiazoly)phenol (cmp2)
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