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[[Image:4def.jpg|left|200px]]


{{STRUCTURE_4def| PDB=4def | SCENE= }}
==Active site loop dynamics of a class IIa fructose 1,6-bisphosphate aldolase from M. tuberculosis==
<StructureSection load='4def' size='340' side='right'caption='[[4def]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4def]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DEF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DEF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.64&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4def FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4def OCA], [https://pdbe.org/4def PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4def RCSB], [https://www.ebi.ac.uk/pdbsum/4def PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4def ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ALF_MYCTU ALF_MYCTU] Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis (By similarity).


===Active site loop dynamics of a class IIa fructose 1,6-bisphosphate aldolase from M. tuberculosis===
==See Also==
 
*[[Aldolase 3D structures|Aldolase 3D structures]]
{{ABSTRACT_PUBMED_23298222}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
[[4def]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DEF OCA].
[[Category: Fructose-bisphosphate aldolase]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Capodagli, G C.]]
[[Category: Capodagli GC]]
[[Category: Pegan, S D.]]
[[Category: Pegan SD]]
[[Category: 6-bisphosphate aldolase]]
[[Category: Aldol condensation]]
[[Category: Class ii fructose-1]]
[[Category: Dihydroxyacetone]]
[[Category: Glyceraldehyde-3-phosphate]]
[[Category: Glycolysis]]
[[Category: Lyase]]
[[Category: Metal-binding]]
[[Category: Zinc enzyme]]
Retrieved from "https://proteopedia.org/4def"