3zkt: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 3zkt is ~~ON HOLD~~

==SOLUTION STRUCTURE OF THE SOMATOSTATIN SST3 RECEPTOR ANTAGONIST TAU- CONOTOXIN CnVA==

== Structural highlights ==

<table><tr><td colspan='2'>[[3zkt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_consors Conus consors]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZKT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZKT FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zkt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zkt OCA], [https://pdbe.org/3zkt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zkt RCSB], [https://www.ebi.ac.uk/pdbsum/3zkt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zkt ProSAT]</span></td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/CT5A_CONCN CT5A_CONCN]

== Publication Abstract from PubMed ==

Conopeptides are a diverse array of small linear and reticulated peptides that interact with high potency and selectivity with a large diversity of receptors and ion channels. They are used by cone snails for prey capture or defense. Recent advances in venom gland transcriptomic and venom peptidomic/proteomic technologies combined with bioactivity screening approaches lead to the identification of new toxins with original pharmacological profiles. Here, from transcriptomic/proteomic analyses of the Conus consors cone snail, we identified a new conopeptide called tau-CnVA, which displays the typical cysteine framework V of the T1-conotoxin superfamily. This peptide was chemically synthesized and its three-dimensional structure was solved by NMR analysis and compared to that of TxVA belonging to the same family, revealing very few common structural features apart a common orientation of the intercysteine loop. Because of the lack of a clear biological function associated with the T-conotoxin family, tau-CnVA was screened against more than fifty different ion channels and receptors, highlighting its capacity to interact selectively with the somatostatine sst3 receptor. Pharmacological and functional studies show that tau-CnVA displays a micromolar (Ki of 1.5muM) antagonist property for the sst3 receptor, being currently the only known toxin to interact with this GPCR subfamily.

~~Authors:~~ Petrel, C., Hocking~~, H.G.~~, Reynaud, M., Favreau, P., Paolini-Bertrand, M., Peigneur, S~~., Upert, G.~~, Tytgat, J., Gilles, N., Hartley, O., Boelens, R., Stocklin, R., Servent, D.

Identification, structural and pharmacological characterization of tau-CnVA, a conopeptide that selectively interacts with somatostatin sst receptor.,Petrel C, Hocking HG, Reynaud M, Upert G, Favreau P, Biass D, Paolini-Bertrand M, Peigneur S, Tytgat J, Gilles N, Hartley O, Boelens R, Stocklin R, Servent D Biochem Pharmacol. 2013 Apr 5. pii: S0006-2952(13)00219-0. doi:, 10.1016/j.bcp.2013.03.019. PMID:23567999<ref>PMID:23567999</ref>

~~Description~~: ~~SOLUTION STRUCTURE OF THE SOMATOSTATIN SST3 RECEPTOR ANTAGONIST TAU~~-~~CONOTOXIN CnVA~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

== References ==

__TOC__

</StructureSection>

[[Category: Conus consors]]

[[Category: Large Structures]]

[[Category: Boelens R]]

[[Category: Favreau P]]

[[Category: Gilles N]]

[[Category: Hartley O]]

[[Category: Hocking HG]]

[[Category: Paolini-Bertrand M]]

[[Category: Peigneur S]]

[[Category: Petrel C]]

[[Category: Reynaud M]]

[[Category: Servent D]]

[[Category: Stocklin R]]

[[Category: Tytgat J]]

[[Category: Upert G]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 3zkt is ON HOLD
+==SOLUTION STRUCTURE OF THE SOMATOSTATIN SST3 RECEPTOR ANTAGONIST TAU- CONOTOXIN CnVA==
+<StructureSection load='3zkt' size='340' side='right'caption='[[3zkt]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3zkt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_consors Conus consors]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZKT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZKT FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zkt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zkt OCA], [https://pdbe.org/3zkt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zkt RCSB], [https://www.ebi.ac.uk/pdbsum/3zkt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zkt ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CT5A_CONCN CT5A_CONCN]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Conopeptides are a diverse array of small linear and reticulated peptides that interact with high potency and selectivity with a large diversity of receptors and ion channels. They are used by cone snails for prey capture or defense. Recent advances in venom gland transcriptomic and venom peptidomic/proteomic technologies combined with bioactivity screening approaches lead to the identification of new toxins with original pharmacological profiles. Here, from transcriptomic/proteomic analyses of the Conus consors cone snail, we identified a new conopeptide called tau-CnVA, which displays the typical cysteine framework V of the T1-conotoxin superfamily. This peptide was chemically synthesized and its three-dimensional structure was solved by NMR analysis and compared to that of TxVA belonging to the same family, revealing very few common structural features apart a common orientation of the intercysteine loop. Because of the lack of a clear biological function associated with the T-conotoxin family, tau-CnVA was screened against more than fifty different ion channels and receptors, highlighting its capacity to interact selectively with the somatostatine sst3 receptor. Pharmacological and functional studies show that tau-CnVA displays a micromolar (Ki of 1.5muM) antagonist property for the sst3 receptor, being currently the only known toxin to interact with this GPCR subfamily.
-Authors: Petrel, C., Hocking, H.G., Reynaud, M., Favreau, P., Paolini-Bertrand, M., Peigneur, S., Upert, G., Tytgat, J., Gilles, N., Hartley, O., Boelens, R., Stocklin, R., Servent, D.
+Identification, structural and pharmacological characterization of tau-CnVA, a conopeptide that selectively interacts with somatostatin sst receptor.,Petrel C, Hocking HG, Reynaud M, Upert G, Favreau P, Biass D, Paolini-Bertrand M, Peigneur S, Tytgat J, Gilles N, Hartley O, Boelens R, Stocklin R, Servent D Biochem Pharmacol. 2013 Apr 5. pii: S0006-2952(13)00219-0. doi:, 10.1016/j.bcp.2013.03.019. PMID:23567999<ref>PMID:23567999</ref>
-Description: SOLUTION STRUCTURE OF THE SOMATOSTATIN SST3 RECEPTOR ANTAGONIST TAU-CONOTOXIN CnVA
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 3zkt" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Conus consors]]
+[[Category: Large Structures]]
+[[Category: Boelens R]]
+[[Category: Favreau P]]
+[[Category: Gilles N]]
+[[Category: Hartley O]]
+[[Category: Hocking HG]]
+[[Category: Paolini-Bertrand M]]
+[[Category: Peigneur S]]
+[[Category: Petrel C]]
+[[Category: Reynaud M]]
+[[Category: Servent D]]
+[[Category: Stocklin R]]
+[[Category: Tytgat J]]
+[[Category: Upert G]]