4iua: Difference between revisions
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New page: '''Unreleased structure''' The entry 4iua is ON HOLD Authors: Tolbert, W.D., Zhou, E., Kovach, A., Melcher, K., Xu, H.E. Description: Crystal Structure of the NK2 Fragment (31-290) of ... |
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==Crystal Structure of the NK2 Fragment (31-290) of the mouse Hepatocyte Growth Factor/Scatter Factor== | |||
<StructureSection load='4iua' size='340' side='right'caption='[[4iua]], [[Resolution|resolution]] 3.05Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4iua]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IUA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IUA FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.05Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iua FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iua OCA], [https://pdbe.org/4iua PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iua RCSB], [https://www.ebi.ac.uk/pdbsum/4iua PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iua ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/HGF_MOUSE HGF_MOUSE] Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.<ref>PMID:20624990</ref> | |||
==See Also== | |||
*[[Hepatocyte growth factor|Hepatocyte growth factor]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Kovach A]] | |||
[[Category: Melcher K]] | |||
[[Category: Tolbert WD]] | |||
[[Category: Xu HE]] | |||
[[Category: Zhou E]] | |||
Latest revision as of 15:31, 20 September 2023
Crystal Structure of the NK2 Fragment (31-290) of the mouse Hepatocyte Growth Factor/Scatter Factor
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