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[[Image:3evi.png|left|200px]]


{{STRUCTURE_3evi| PDB=3evi | SCENE= }}
==Crystal structure of the thioredoxin-fold domain of human phosducin-like protein 2==
<StructureSection load='3evi' size='340' side='right'caption='[[3evi]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3evi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EVI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EVI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3evi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3evi OCA], [https://pdbe.org/3evi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3evi RCSB], [https://www.ebi.ac.uk/pdbsum/3evi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3evi ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PDCL2_HUMAN PDCL2_HUMAN] May play a role in germ cell maturation (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ev/3evi_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3evi ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Human phosducin-like protein 2 (hPDCL2) has been identified as belonging to subgroup II of the phosducin (Pdc) family. The members of this family share an N-terminal helix domain and a C-terminal thioredoxin-fold (Trx-fold) domain. The X-ray crystal structure of the Trx-fold domain of hPDCL2 was solved at 2.70 A resolution and resembled the Trx-fold domain of rat phosducin. Comparative structural analysis revealed the structural basis of their putative functional divergence.


===Crystal structure of the thioredoxin-fold domain of human phosducin-like protein 2===
Structure of the thioredoxin-fold domain of human phosducin-like protein 2.,Lou X, Bao R, Zhou CZ, Chen Y Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Feb 1;65(Pt, 2):67-70. Epub 2009 Jan 31. PMID:19193988<ref>PMID:19193988</ref>


{{ABSTRACT_PUBMED_19193988}}
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
==About this Structure==
<div class="pdbe-citations 3evi" style="background-color:#fffaf0;"></div>
[[3evi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EVI OCA].
== References ==
 
<references/>
==Reference==
__TOC__
<ref group="xtra">PMID:019193988</ref><references group="xtra"/>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Bao, R.]]
[[Category: Large Structures]]
[[Category: Chen, Y.]]
[[Category: Bao R]]
[[Category: Lou, X.]]
[[Category: Chen Y]]
[[Category: Zhou, C.]]
[[Category: Lou X]]
[[Category: Alpha beta]]
[[Category: Zhou C]]
[[Category: Unknown function]]

Latest revision as of 15:23, 1 November 2023

Crystal structure of the thioredoxin-fold domain of human phosducin-like protein 2

3evi, resolution 2.70Å

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