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[[Image:3ewk.png|left|200px]]


{{STRUCTURE_3ewk| PDB=3ewk | SCENE= }}
==Structure of the redox sensor domain of Methylococcus capsulatus (Bath) MmoS==
<StructureSection load='3ewk' size='340' side='right'caption='[[3ewk]], [[Resolution|resolution]] 2.34&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3ewk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methylococcus_capsulatus Methylococcus capsulatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EWK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EWK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.34&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ewk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ewk OCA], [https://pdbe.org/3ewk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ewk RCSB], [https://www.ebi.ac.uk/pdbsum/3ewk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ewk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q609M8_METCA Q609M8_METCA]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ew/3ewk_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ewk ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
MmoS from Methylococcus capsulatus (Bath) is the multidomain sensor protein of a two-component signaling system proposed to play a role in the copper-mediated regulation of soluble methane monooxygenase (sMMO). MmoS binds an FAD cofactor within its N-terminal tandem Per-Arnt-Sim (PAS) domains, suggesting that it functions as a redox sensor. The crystal structure of the MmoS tandem PAS domains, designated PAS-A and PAS-B, has been determined to 2.34 A resolution. Both domains adopt the typical PAS domain alpha/beta topology and are structurally similar. The two domains are linked by a long alpha helix and do not interact with one another. The FAD cofactor is housed solely within PAS-A and is stabilized by an extended hydrogen bonding network. The overall fold of PAS-A is similar to those of other flavin-containing PAS domains, but homodimeric interactions in other structures are not observed in the MmoS sensor, which crystallized as a monomer. The structure both provides new insight into the architecture of tandem PAS domains and suggests specific residues that may play a role in MmoS FAD redox chemistry and subsequent signal transduction.


===Structure of the redox sensor domain of Methylococcus capsulatus (Bath) MmoS===
Structure of the Redox Sensor Domain of Methylococcus capsulatus (Bath) MmoS (dagger) (double dagger).,Ukaegbu UE, Rosenzweig AC Biochemistry. 2009 Mar 17;48(10):2207-15. PMID:19271777<ref>PMID:19271777</ref>


{{ABSTRACT_PUBMED_19271777}}
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
==About this Structure==
<div class="pdbe-citations 3ewk" style="background-color:#fffaf0;"></div>
[[3ewk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylococcus_capsulatus Methylococcus capsulatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EWK OCA].
== References ==
 
<references/>
==Reference==
__TOC__
<ref group="xtra">PMID:019271777</ref><references group="xtra"/>
</StructureSection>
[[Category: Histidine kinase]]
[[Category: Large Structures]]
[[Category: Methylococcus capsulatus]]
[[Category: Methylococcus capsulatus]]
[[Category: Rosenzweig, A C.]]
[[Category: Rosenzweig AC]]
[[Category: Ukaegbu, U E.]]
[[Category: Ukaegbu UE]]
[[Category: Alpha/beta fold]]
[[Category: Flavoprotein]]
[[Category: Kinase]]
[[Category: Pas domain]]
[[Category: Phosphoprotein]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/3ewk"