3eqw: Difference between revisions

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[[Image:3eqw.png|left|200px]]


{{STRUCTURE_3eqw| PDB=3eqw | SCENE= }}  
==A bimolecular anti-parallel-stranded Oxytricha nova telomeric quadruplex in complex with a 3,6-disubstituted acridine BSU-6042 in small unit cell==
<StructureSection load='3eqw' size='340' side='right'caption='[[3eqw]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3eqw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EQW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EQW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NCI:3,6-BIS{3-[(2R)-(2-ETHYLPIPERIDINO)]PROPIONAMIDO}ACRIDINE'>NCI</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eqw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eqw OCA], [https://pdbe.org/3eqw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eqw RCSB], [https://www.ebi.ac.uk/pdbsum/3eqw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eqw ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
A series of disubstituted acridine ligands have been cocrystallized with a bimolecular DNA G-quadruplex. The ligands have a range of cyclic amino end groups of varying size. The crystal structures show that the diagonal loop in this quadruplex results in a large cavity for these groups, in contrast to the steric constraints imposed by propeller loops in human telomeric quadruplexes. We conclude that the nature of the loop has a significant influence on ligand selectivity for particular quadruplex folds.


===A bimolecular anti-parallel-stranded Oxytricha nova telomeric quadruplex in complex with a 3,6-disubstituted acridine BSU-6042 in small unit cell===
Selectivity in Ligand Recognition of G-Quadruplex Loops (dagger).,Campbell NH, Patel M, Tofa AB, Ghosh R, Parkinson GN, Neidle S Biochemistry. 2009 Feb 4. PMID:19173611<ref>PMID:19173611</ref>


{{ABSTRACT_PUBMED_19173611}}
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
==About this Structure==
<div class="pdbe-citations 3eqw" style="background-color:#fffaf0;"></div>
[[3eqw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EQW OCA].
== References ==
 
<references/>
==Reference==
__TOC__
<ref group="xtra">PMID:019173611</ref><references group="xtra"/>
</StructureSection>
[[Category: Campbell, N H.]]
[[Category: Large Structures]]
[[Category: Neidle, S.]]
[[Category: Campbell NH]]
[[Category: Parkinson, G.]]
[[Category: Neidle S]]
[[Category: Anti-parallel]]
[[Category: Parkinson G]]
[[Category: Bimolecular]]
[[Category: Bsu-6042]]
[[Category: Bsu6042]]
[[Category: Dna]]
[[Category: G-quadruplex]]
[[Category: Macromlecule]]
[[Category: Oxytricha nova]]
[[Category: Quadruplex]]
[[Category: Telomere]]
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