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[[Image:3vd8.png|left|200px]]


{{STRUCTURE_3vd8| PDB=3vd8 | SCENE= }}
==Crystal structure of human AIM2 PYD domain with MBP fusion==
<StructureSection load='3vd8' size='340' side='right'caption='[[3vd8]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3vd8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VD8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VD8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.0685&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PRD_900010:alpha-maltotetraose'>PRD_900010</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vd8 OCA], [https://pdbe.org/3vd8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vd8 RCSB], [https://www.ebi.ac.uk/pdbsum/3vd8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vd8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AIM2_HUMAN AIM2_HUMAN] Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.<ref>PMID:16432157</ref> <ref>PMID:17726700</ref> <ref>PMID:19158679</ref> <ref>PMID:19158676</ref> <ref>PMID:19158675</ref> <ref>PMID:20566831</ref> [https://www.uniprot.org/uniprot/MALE_ECO57 MALE_ECO57] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides (By similarity).


===Crystal structure of human AIM2 PYD domain with MBP fusion===
==See Also==
 
*[[Pyrin domain|Pyrin domain]]
 
== References ==
==About this Structure==
<references/>
[[3vd8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VD8 OCA].
__TOC__
[[Category: Jin, T C.]]
</StructureSection>
[[Category: Perry, A.]]
[[Category: Escherichia coli O157:H7]]
[[Category: Smith, P.]]
[[Category: Homo sapiens]]
[[Category: Xiao, T S.]]
[[Category: Large Structures]]
[[Category: Inflammasome]]
[[Category: Jin TC]]
[[Category: Mbp/pyd/dd]]
[[Category: Perry A]]
[[Category: Signal transduction]]
[[Category: Smith P]]
[[Category: Signaling protein]]
[[Category: Xiao TS]]
[[Category: Sugar binding protein]]
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