4ibf: Difference between revisions
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==Ebola virus VP35 bound to small molecule== | |||
<StructureSection load='4ibf' size='340' side='right'caption='[[4ibf]], [[Resolution|resolution]] 2.29Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4ibf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ebola_virus_-_Mayinga,_Zaire,_1976 Ebola virus - Mayinga, Zaire, 1976]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IBF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IBF FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.291Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1D5:(4-{(2R)-2-(4-BROMOTHIOPHEN-2-YL)-3-[(5-CHLOROTHIOPHEN-2-YL)CARBONYL]-4-HYDROXY-5-OXO-2,5-DIHYDRO-1H-PYRROL-1-YL}PHENYL)ACETIC+ACID'>1D5</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ibf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ibf OCA], [https://pdbe.org/4ibf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ibf RCSB], [https://www.ebi.ac.uk/pdbsum/4ibf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ibf ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/VP35_EBOZM VP35_EBOZM] Acsts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR.<ref>PMID:9971816</ref> <ref>PMID:11027311</ref> <ref>PMID:12829834</ref> <ref>PMID:16495261</ref> <ref>PMID:17065211</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Ebola virus - Mayinga, Zaire, 1976]] | |||
[[Category: Large Structures]] | |||
[[Category: Amarasinghe GK]] | |||
[[Category: Binning JM]] | |||
[[Category: Borek DM]] | |||
[[Category: Brown CS]] | |||
[[Category: Leung DW]] | |||
[[Category: Otwinowski Z]] | |||
[[Category: Peterson DS]] | |||
[[Category: Ramanan P]] | |||
[[Category: Stubbs AJ]] | |||
[[Category: Xu W]] | |||
Latest revision as of 11:52, 1 March 2024
Ebola virus VP35 bound to small molecule
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