4j1o: Difference between revisions
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New page: '''Unreleased structure''' The entry 4j1o is ON HOLD Authors: Vetting, M.W., Toro, R., Bhosle, R., Wasserman, S.R., Morisco, L.L., Sojitra, S., Chamala,S., Kar, A., LaFleur, J., Villiga... |
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==Crystal structure of an enolase (mandelate racemase subgroup) from paracococus denitrificans pd1222 (target nysgrc-012907) with bound l-proline betaine (substrate)== | |||
<StructureSection load='4j1o' size='340' side='right'caption='[[4j1o]], [[Resolution|resolution]] 1.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4j1o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Paracoccus_denitrificans_PD1222 Paracoccus denitrificans PD1222]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J1O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J1O FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PBE:1,1-DIMETHYL-PROLINIUM'>PBE</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j1o OCA], [https://pdbe.org/4j1o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j1o RCSB], [https://www.ebi.ac.uk/pdbsum/4j1o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j1o ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/HPBD_PARDP HPBD_PARDP] Catalyzes the 2-epimerization of trans-4-hydroxy-L-proline betaine (tHyp-B) to cis-4-hydroxy-D-proline betaine (cHyp-B). Is involved in a catabolic pathway that degrades tHyp-B to alpha-ketoglutarate. This pathway would permit the utilization of tHyp-B as a carbon and nitrogen source in the absence of osmotic stress, since tHyp-B functions as an osmolyte and is not catabolized when it is needed as osmoprotectant. Can also catalyze the racemization of L-proline betaine.<ref>PMID:24056934</ref> | |||
==See Also== | |||
*[[Mandelate racemase/muconate lactonizing enzyme 3D structures|Mandelate racemase/muconate lactonizing enzyme 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Paracoccus denitrificans PD1222]] | |||
[[Category: Almo SC]] | |||
[[Category: Bhosle R]] | |||
[[Category: Bonanno JB]] | |||
[[Category: Chamala S]] | |||
[[Category: Evans B]] | |||
[[Category: Gerlt JA]] | |||
[[Category: Gizzi A]] | |||
[[Category: Hammonds J]] | |||
[[Category: Hillerich B]] | |||
[[Category: Kar A]] | |||
[[Category: LaFleur J]] | |||
[[Category: Love J]] | |||
[[Category: Morisco LL]] | |||
[[Category: Seidel RD]] | |||
[[Category: Sojitra S]] | |||
[[Category: Stead M]] | |||
[[Category: Toro R]] | |||
[[Category: Vetting MW]] | |||
[[Category: Villigas G]] | |||
[[Category: Wasserman SR]] | |||
