4elb: Difference between revisions
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==Structure-activity relationship guides enantiomeric preference among potent inhibitors of B. anthracis dihydrofolate reductase== | |||
<StructureSection load='4elb' size='340' side='right'caption='[[4elb]], [[Resolution|resolution]] 2.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4elb]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis_str._Sterne Bacillus anthracis str. Sterne]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ELB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ELB FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=34R:(2E)-3-{5-[(2,4-DIAMINOPYRIMIDIN-5-YL)METHYL]-2,3-DIMETHOXYPHENYL}-1-[(1R)-1-PHENYLPHTHALAZIN-2(1H)-YL]PROP-2-EN-1-ONE'>34R</scene>, <scene name='pdbligand=34S:(2E)-3-{5-[(2,4-DIAMINOPYRIMIDIN-5-YL)METHYL]-2,3-DIMETHOXYPHENYL}-1-[(1S)-1-PHENYLPHTHALAZIN-2(1H)-YL]PROP-2-EN-1-ONE'>34S</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4elb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4elb OCA], [https://pdbe.org/4elb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4elb RCSB], [https://www.ebi.ac.uk/pdbsum/4elb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4elb ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/Q81R22_BACAN Q81R22_BACAN] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194] | |||
== | ==See Also== | ||
*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Bacillus anthracis str. Sterne]] | |||
[[ | [[Category: Large Structures]] | ||
[[Category: Bacillus anthracis str. | [[Category: Barrow WW]] | ||
[[Category: | [[Category: Bourne CR]] | ||
[[Category: Barrow | |||
[[Category: Bourne | |||
Latest revision as of 15:04, 14 March 2024
Structure-activity relationship guides enantiomeric preference among potent inhibitors of B. anthracis dihydrofolate reductase
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