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[[Image:4don.jpg|left|200px]]


{{STRUCTURE_4don| PDB=4don | SCENE= }}
==Brd4 Bromodomain 1 complex with a fragment 3,4-Dihydro-3-methyl-2(1H)-quinazolinon==
<StructureSection load='4don' size='340' side='right'caption='[[4don]], [[Resolution|resolution]] 1.52&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4don]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DON OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DON FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.52&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PF:3-METHYL-3,4-DIHYDROQUINAZOLIN-2(1H)-ONE'>3PF</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4don FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4don OCA], [https://pdbe.org/4don PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4don RCSB], [https://www.ebi.ac.uk/pdbsum/4don PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4don ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
== Function ==
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).


===Brd4 Bromodomain 1 complex with a fragment 3,4-Dihydro-3-methyl-2(1H)-quinazolinon===
==See Also==
 
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
 
== References ==
==About this Structure==
<references/>
[[4don]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DON OCA].
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Cao, D Y.]]
[[Category: Large Structures]]
[[Category: Chen, T T.]]
[[Category: Cao DY]]
[[Category: Chen, W Y.]]
[[Category: Chen TT]]
[[Category: Shen, J K.]]
[[Category: Chen WY]]
[[Category: Xiong, B.]]
[[Category: Shen JK]]
[[Category: Xu, Y C.]]
[[Category: Xiong B]]
[[Category: Brd4]]
[[Category: Xu YC]]
[[Category: Bromodomain]]
[[Category: Four alpha helice]]
[[Category: Signaling protein]]
Retrieved from "https://proteopedia.org/4don"