3gf5: Difference between revisions
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==Crystal structure of the P21 R1-R7 N-terminal domain of murine MVP== | |||
<StructureSection load='3gf5' size='340' side='right'caption='[[3gf5]], [[Resolution|resolution]] 2.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3gf5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GF5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GF5 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |||
== | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gf5 OCA], [https://pdbe.org/3gf5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gf5 RCSB], [https://www.ebi.ac.uk/pdbsum/3gf5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gf5 ProSAT]</span></td></tr> | ||
[[3gf5]] is a 2 chain structure with sequence from [ | </table> | ||
== Function == | |||
== | [https://www.uniprot.org/uniprot/MVP_MOUSE MVP_MOUSE] Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases (By similarity). | ||
< | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gf/3gf5_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gf5 ConSurf]. | |||
<div style="clear:both"></div> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Casanas | [[Category: Casanas A]] | ||
[[Category: Caston | [[Category: Caston JR]] | ||
[[Category: Fita | [[Category: Fita I]] | ||
[[Category: Luque | [[Category: Luque D]] | ||
[[Category: Querol-Audi | [[Category: Querol-Audi J]] | ||
[[Category: Verdaguer | [[Category: Verdaguer N]] | ||
Latest revision as of 08:26, 20 March 2024
Crystal structure of the P21 R1-R7 N-terminal domain of murine MVP
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