2m52: Difference between revisions
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New page: '''Unreleased structure''' The entry 2m52 is ON HOLD Authors: Dutta, S.K., Serrano, P., Geralt, M., Wuthrich, K. Description: NMR Structure of the third RNA Recognition Motif (RRM) of ... |
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==NMR Structure of the third RNA Recognition Motif (RRM) of U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2== | |||
<StructureSection load='2m52' size='340' side='right'caption='[[2m52]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2m52]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M52 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M52 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m52 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m52 OCA], [https://pdbe.org/2m52 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m52 RCSB], [https://www.ebi.ac.uk/pdbsum/2m52 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m52 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/U2AF2_MOUSE U2AF2_MOUSE] Necessary for the splicing of pre-mRNA. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10 (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Dutta SK]] | |||
[[Category: Geralt M]] | |||
[[Category: Serrano P]] | |||
[[Category: Wuthrich K]] | |||
Latest revision as of 05:59, 15 May 2024
NMR Structure of the third RNA Recognition Motif (RRM) of U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2
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