4ieg: Difference between revisions

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'''Unreleased structure'''


The entry 4ieg is ON HOLD  until Paper Publication
==Structure and interactions of the RNA-dependent RNA polymerase from bacteriophage phi12 (P1 crystal form)==
<StructureSection load='4ieg' size='340' side='right'caption='[[4ieg]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4ieg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_phage_phi12 Pseudomonas phage phi12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IEG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IEG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ieg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ieg OCA], [https://pdbe.org/4ieg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ieg RCSB], [https://www.ebi.ac.uk/pdbsum/4ieg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ieg ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q94M06_9VIRU Q94M06_9VIRU]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
We have determined the structure of P2, the self-priming RdRp from cystovirus varphi12 in two crystal forms (A, B) at resolutions of 1.7 A and 2.1 A. Form A contains Mg(2+) bound at a site that deviates from the canonical noncatalytic position seen in form B. These structures provide insight into the temperature sensitivity of a ts-mutant. However, the tunnel through which template ssRNA accesses the active site is partially occluded by a flexible loop; this feature, along with suboptimal positioning of other structural elements that prevent the formation of a stable initiation complex, indicate an inactive conformation in crystallo. Proteins 2013; 81:1479-1484. (c) 2013 Wiley Periodicals, Inc.


Authors: Ren, Z., Franklin, M.C., Ghose, R.
Structure of the RNA-directed RNA Polymerase from the cystovirus varphi12.,Ren Z, C Franklin M, Ghose R Proteins. 2013 Aug;81(8):1479-84. doi: 10.1002/prot.24297. Epub 2013 Jun 1. PMID:23568335<ref>PMID:23568335</ref>


Description: Structure and interactions of the RNA-dependent RNA polymerase from bacteriophage phi12 (P1 crystal form)
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4ieg" style="background-color:#fffaf0;"></div>
 
==See Also==
*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pseudomonas phage phi12]]
[[Category: Franklin MC]]
[[Category: Ghose R]]
[[Category: Ren Z]]
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