4j7e: Difference between revisions
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The | ==The 1.63A crystal structure of humanized Xenopus MDM2 with a nutlin fragment, RO5524529== | ||
<StructureSection load='4j7e' size='340' side='right'caption='[[4j7e]], [[Resolution|resolution]] 1.63Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4j7e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J7E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J7E FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.63Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I29:[(4S,5R)-4,5-BIS(4-CHLOROPHENYL)-2,4,5-TRIMETHYL-4,5-DIHYDRO-1H-IMIDAZOL-1-YL]{4-[3-(METHYLSULFONYL)PROPYL]PIPERAZIN-1-YL}METHANONE'>I29</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j7e OCA], [https://pdbe.org/4j7e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j7e RCSB], [https://www.ebi.ac.uk/pdbsum/4j7e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j7e ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/MDM2_XENLA MDM2_XENLA] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degration by the proteasome (By similarity). | |||
==See Also== | |||
*[[MDM2 3D structures|MDM2 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Xenopus laevis]] | |||
[[Category: Graves B]] | |||
[[Category: Janson C]] | |||
[[Category: Lukacs C]] | |||
Latest revision as of 12:01, 1 March 2024
The 1.63A crystal structure of humanized Xenopus MDM2 with a nutlin fragment, RO5524529
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