4j7l: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 4j7l is ~~ON HOLD~~

==Crystal structure of mouse DXO in complex with PRODUCT RNA AND two MAGNESIUM ions==

~~Authors~~: ~~Chang~~, J.H., ~~Kilic~~, T., ~~Tong~~, L.

== Structural highlights ==

<table><tr><td colspan='2'>[[4j7l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J7L OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=4J7L FirstGlance].

~~Description~~: ~~Crystal structure~~ of ~~mouse DXO in complex with product~~ RNA and ~~magnesium~~

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UBD:URIDINE+3,5-BIS(DIHYDROGEN+PHOSPHATE)'>UBD</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=4j7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j7l OCA], [https://pdbe.org/4j7l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j7l RCSB], [https://www.ebi.ac.uk/pdbsum/4j7l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j7l ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/DXO_MOUSE DXO_MOUSE] Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5'-3' exonuclease activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. The 5' end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates.<ref>PMID:23523372</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Mus musculus]]

[[Category: Synthetic construct]]

[[Category: Chang JH]]

[[Category: Tong L]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4j7l is ON HOLD
+==Crystal structure of mouse DXO in complex with PRODUCT RNA AND two MAGNESIUM ions==
+<StructureSection load='4j7l' size='340' side='right'caption='[[4j7l]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-Authors: Chang, J.H., Kilic, T., Tong, L.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4j7l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J7L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J7L FirstGlance]. <br>
-Description: Crystal structure of mouse DXO in complex with product RNA and magnesium
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UBD:URIDINE+3,5-BIS(DIHYDROGEN+PHOSPHATE)'>UBD</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j7l OCA], [https://pdbe.org/4j7l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j7l RCSB], [https://www.ebi.ac.uk/pdbsum/4j7l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j7l ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/DXO_MOUSE DXO_MOUSE] Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5'-3' exonuclease activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. The 5' end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates.<ref>PMID:23523372</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Mus musculus]]
+[[Category: Synthetic construct]]
+[[Category: Chang JH]]
+[[Category: Tong L]]