4jbj: Difference between revisions
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New page: '''Unreleased structure''' The entry 4jbj is ON HOLD Authors: Ru, H., Ni, X.-M., Ma, F., Zhao, L.-X., Ding, W., Hung, L.-W., Shaw, N., Cheng, G.-H., Liu, Z.-J. Description: HINa domain... |
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==Structural mimicry for functional antagonism== | |||
<StructureSection load='4jbj' size='340' side='right'caption='[[4jbj]], [[Resolution|resolution]] 2.69Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4jbj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JBJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JBJ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.692Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jbj OCA], [https://pdbe.org/4jbj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jbj RCSB], [https://www.ebi.ac.uk/pdbsum/4jbj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jbj ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/IFI2_MOUSE IFI2_MOUSE] Inhibits the transcriptional activity of several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin. Has anti-apoptotic effects due to inhibition of the transcriptional activity of p53. Binds dsDNA in the cytosol. Is involved in innate immune response and has anti-inflammatory activity. Inhibits caspase activation in response to cytosolic DNA and may inhibit the activation of the AIM2 inflammasome, probably via association with AIM2.<ref>PMID:16670293</ref> <ref>PMID:19131592</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Cheng G]] | |||
[[Category: Ding W]] | |||
[[Category: Hung L-W]] | |||
[[Category: Liu Z-J]] | |||
[[Category: Ma F]] | |||
[[Category: Ni X]] | |||
[[Category: Ru H]] | |||
[[Category: Shaw N]] | |||
[[Category: Zhao L]] | |||
Latest revision as of 14:22, 8 November 2023
Structural mimicry for functional antagonism
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