3gqv: Difference between revisions

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[[Image:3gqv.png|left|200px]]


{{STRUCTURE_3gqv|  PDB=3gqv  |  SCENE=  }}
==Lovastatin polyketide enoyl reductase (LovC) mutant K54S with bound NADP==
 
<StructureSection load='3gqv' size='340' side='right'caption='[[3gqv]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
===Lovastatin polyketide enoyl reductase (LovC) mutant K54S with bound NADP===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3gqv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_terreus Aspergillus terreus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GQV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GQV FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
[[3gqv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspergillus_terreus Aspergillus terreus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GQV OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gqv OCA], [https://pdbe.org/3gqv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gqv RCSB], [https://www.ebi.ac.uk/pdbsum/3gqv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gqv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LOVC_ASPTE LOVC_ASPTE] Catalyzes the NADPH-dependent reduction of the unsaturated tetra-, penta- and heptaketide intermediates that arise during the LovB-mediated biosynthesis of the lovastatin nonaketide chain.<ref>PMID:10334994</ref> <ref>PMID:19900898</ref> <ref>PMID:22733743</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gq/3gqv_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gqv ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Aspergillus terreus]]
[[Category: Aspergillus terreus]]
[[Category: Ames, B D.]]
[[Category: Large Structures]]
[[Category: Kaake, R.]]
[[Category: Ames BD]]
[[Category: Li, J W.]]
[[Category: Kaake R]]
[[Category: Ma, S M.]]
[[Category: Li JW]]
[[Category: Smith, P T.]]
[[Category: Ma SM]]
[[Category: Tang, Y.]]
[[Category: Smith PT]]
[[Category: Tsai, S C.]]
[[Category: Tang Y]]
[[Category: Vederas, J C.]]
[[Category: Tsai S-C]]
[[Category: Wong, E W.]]
[[Category: Vederas JC]]
[[Category: Wong, S K.]]
[[Category: Wong EW]]
[[Category: Xie, X.]]
[[Category: Wong SK]]
[[Category: Nadp-binding]]
[[Category: Xie X]]
[[Category: Oxidoreductase]]
[[Category: Rossmann fold]]
Retrieved from "https://proteopedia.org/3gqv"