4jek: Difference between revisions
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New page: '''Unreleased structure''' The entry 4jek is ON HOLD Authors: Zhang, L., Duan, X.L., Zhou, D.M., Li, X. Description: Structure of dibenzothiophene monooxygenase (DszC) from Rhodococcus... |
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==Structure of dibenzothiophene monooxygenase (DszC) from Rhodococcus erythropolis== | |||
<StructureSection load='4jek' size='340' side='right'caption='[[4jek]], [[Resolution|resolution]] 2.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4jek]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodococcus_sp._IGTS8 Rhodococcus sp. IGTS8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JEK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JEK FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jek FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jek OCA], [https://pdbe.org/4jek PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jek RCSB], [https://www.ebi.ac.uk/pdbsum/4jek PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jek ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DSZC_RHOSG DSZC_RHOSG] Catalyzes the first step of the '4S' desulfurization pathway that removes covalently bound sulfur from dibenzothiophene (DBT) without breaking carbon-carbon bonds. Sulfur dioxygenase which converts DBT to DBT-sulfone (DBTO2 or DBT 5,5-dioxide) in a stepwise manner. In (PubMed:7961424) DBTO (dibenzothiophene-5-oxide) was reported not to be a substrate, in (PubMed:7574582, PubMed:9634856, PubMed:8824615 and PubMed:9308179) it is reported to be a substrate (PubMed:7961424, PubMed:7574582, PubMed:9634856, PubMed:8824615, PubMed:9308179). Can also use benzyl sulfide and benzyl sulfoxide as substrates, although benzyl sulfoxide is a poor substrate (PubMed:8824615). The pathway substrate specificity has been augmented using mutagenesis, however no mutations allowed use of alkylated thiophenes (PubMed:11823208).<ref>PMID:11823208</ref> <ref>PMID:7574582</ref> <ref>PMID:7961424</ref> <ref>PMID:8824615</ref> <ref>PMID:9308179</ref> <ref>PMID:9634856</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Rhodococcus sp. IGTS8]] | |||
[[Category: Duan XL]] | |||
[[Category: Li X]] | |||
[[Category: Zhang L]] | |||
[[Category: Zhou DM]] | |||
