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[[Image:2awa.gif|left|200px]]<br /><applet load="2awa" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2awa, resolution 2.500&Aring;" />
'''Crystal structure of DNA polymerase III, beta chain (EC 2.7.7.7) (np_344555.1) from STREPTOCOCCUS PNEUMONIAE TIGR4 at 2.50 A resolution'''<br />


==About this Structure==
==Crystal structure of DNA polymerase III, beta chain (EC 2.7.7.7) (np_344555.1) from STREPTOCOCCUS PNEUMONIAE TIGR4 at 2.50 A resolution==
2AWA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae_tigr4 Streptococcus pneumoniae tigr4] with <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AWA OCA].
<StructureSection load='2awa' size='340' side='right'caption='[[2awa]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
[[Category: DNA-directed DNA polymerase]]
== Structural highlights ==
[[Category: Single protein]]
<table><tr><td colspan='2'>[[2awa]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_TIGR4 Streptococcus pneumoniae TIGR4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AWA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AWA FirstGlance]. <br>
[[Category: Streptococcus pneumoniae tigr4]]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
[[Category: JCSG, Joint Center for Structural Genomics.]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
[[Category: GOL]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2awa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2awa OCA], [https://pdbe.org/2awa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2awa RCSB], [https://www.ebi.ac.uk/pdbsum/2awa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2awa ProSAT], [https://www.topsan.org/Proteins/JCSG/2awa TOPSAN]</span></td></tr>
[[Category: beta chain (ec 2 7.7 7)]]
</table>
[[Category: dna polymerase iii]]
== Function ==
[[Category: jcsg]]
[https://www.uniprot.org/uniprot/DPO3B_STRPN DPO3B_STRPN] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA (By similarity).
[[Category: joint center for structural genomics]]
== Evolutionary Conservation ==
[[Category: np_344555 1]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: protein structure initiative]]
Check<jmol>
[[Category: psi]]
  <jmolCheckbox>
[[Category: structural genomics]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aw/2awa_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2awa ConSurf].
<div style="clear:both"></div>


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:31:47 2008''
==See Also==
*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Streptococcus pneumoniae TIGR4]]
Retrieved from "https://proteopedia.org/2awa"